AI Article Synopsis
- The study aimed to evaluate the effectiveness of the Montreal Cognitive Assessment (MoCA) and the Alzheimer's Disease-8 (AD8) in identifying cognitive impairment among 111 patients with Parkinson's Disease (PD).
- The MoCA demonstrated a classification accuracy of 78.4% with a good area under the curve (AUC) of 0.82, suggesting it is a reliable tool, especially with a cutoff score of less than 25 for optimal sensitivity and specificity.
- In contrast, the AD8 did not show statistical significance for identifying cognitive impairment in this population, with a lower classification rate of 70.5% and an AUC of 0.50, indicating it may not be suitable for use in
Article Abstract
Objective: To examine the sensitivity and specificity of the Montreal Cognitive Assessment (MoCA), a brief cognitive screening measure previously validated for use in Parkinson's disease (PD), and Alzheimer's Disease-8 (AD8), an eight-item informant report used to screen for dementia, but not yet validated for use in PD, to identify cognitive impairment in a sample of 111 patients with PD.
Methods: Cognitive impairment was determined based on a battery of neuropsychological measures, excluding the MoCA and AD8. Classification rates of both the MoCA and AD8 in identifying cognitive impairment were examined using logistic regression and receiver operator characteristic (ROC) analysis. Optimal cutoff scores were determined to maximize sensitivity and specificity.
Results: The MoCA correctly classified 78.4% of participants (p < 0.001), and ROC analysis yielded an area under the curve (AUC) of 0.82. A MoCA cutoff score of <25 yielded optimal sensitivity (0.77) and specificity (0.79) for identifying PD patients with cognitive impairment. Similar analyses for the AD8 were statistically nonsignificant, although the classification rate was 70.5%, with an AUC of 0.50.
Conclusions: These results provide additional support for the MoCA, but not the AD8, in identifying cognitive impairment in patients with PD.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524653 | PMC |
| http://dx.doi.org/10.1002/gps.4320 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!