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CRISPR-Cas9 screening identifies the role of FER as a tumor suppressor.
J Pathol
February 2025
Army Medical University, Chongqing, PR China.
It is important to systematically identify tumor suppressor genes (TSGs) to improve our understanding of tumorigenesis and develop strategies for early diagnosis and mitigating disease progression. In the present study, we used an in vivo genome-wide clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (Cas9) screen and identified FPS/FES-related (FER) as a TSG. Single-cell RNA sequencing (scRNA-seq) revealed that normal cells with low FER expression exhibited elevated malignant transformation potential and stemness properties.
View Article and Find Full Text PDFFrequency and clinical characteristics of children and young people with type 2 diabetes at diagnosis from five world regions between 2012 and 2021: data from the SWEET Registry.
Diabetologia
January 2025
Department of Women's and Children's Health, Azienda Ospedaliero/Universitaria delle Marche, 'G. Salesi Hospital', Ancona, Italy.
Aims/hypothesis: The diagnosis of type 2 diabetes is increasing in young people worldwide. This study evaluated the frequency and clinical characteristics of young people presenting with type 2 diabetes from the multinational SWEET e.V Registry 2012-2021, including the first years of the COVID-19 pandemic.
View Article and Find Full Text PDFMapping the relationship between atopic dermatitis and gut microbiota: a bibliometric analysis, 2014-2023.
Front Microbiol
September 2024
Department of Dermatology, Shanghai Fourth People 's Hospital, Tongji University School of Medicine, Shanghai, China.
Article Synopsis
- - Atopic dermatitis (AD) is a chronic skin condition affecting many people, particularly children, and has significant impacts on both physical health and mental well-being; research suggests that gut microbiota may play a role in managing AD symptoms.
- - A study analyzed 804 articles from 2014 to 2023, revealing a steady increase in research on the connection between AD and gut microbiota, primarily led by institutions in the United States and specific universities.
- - The findings highlighted key themes such as "atopic dermatitis" and "gut microbiota," showing a shift in research focus over time, particularly from initial studies on fecal microbiota to broader investigations of dietary and microbial influences on AD.
Novel p.Asp27Glu ACTA1 variant features congenital myopathy with finger flexor weakness, cardiomyopathy, and cardiac conduction defects.
Neuromuscul Disord
July 2023
Division of Neurology, Department of Medicine, University of Alberta, 7-125 Clinical Sciences Building 11350 83rd Avenue NW, Edmonton, AB, Canada T6G 2G3. Electronic address:
Pathogenic variants in the skeletal muscle α-actin 1 gene (ACTA1) cause a spectrum of myopathies with clinical and myopathological diversity. Clinical presentations occur from the prenatal period to adulthood, commonly with proximal-predominant weakness and rarely preferential distal weakness. Myopathological findings are wide-ranging, with nemaline rods being most frequent.
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