HISTOLOGICAL AND IMMUNOHISTOCHEMICAL STUDIES OF ATHEROSCLEROTIC AND SENILE CALCIFIC AORTIC VALVE STENOSIS.

THE GOAL OF THIS STUDY: description of morphogenesis aortic valve stenosis in the senile and vice atherosclerotic aortic valve and definition inflammatory processes in them, improving pathology-anatomic diagnostic, macro- and microscopic examination of the stage of development of atherosclerotic plaques in the operating material fragments of aortic valve on the basis of morphological (histochemical and immunohistochemical studies by using markers CD31, VEGF) and idiopathic characteristics of atherosclerotic plaques, the differential diagnosis of the degree of calcification of the aortic valve in the atherogenic and idiopathic aortic stenosis. Calcification in senile aortic stenosis is characterized by three main parameters: infiltration of inflammatory cells, while senile origin stenosis observed the potential growth of angiogenesis. In endothelial walls of the aortic valve imunnhistochemicaly revealed high expression of endothelial and panendothelial growth factors. We have investigated aortic valve leaflets which were obtained from patients undergoing aortic valve replacement. Total 65 Patients (there age were from 54-84 year), 35 male and 30 female. The results indicate that senile lesion of aortic valve leaflets have several features including: sclera-fibrosis, inflammatory cell infiltration, new vessels formation and calcification which also are present in clinically stenotic valves cased by atherosclerosis. As a result of overlap clinical factors within atherosclerosis and senile calcific disease may be determined such as factors contributing progress of obstruction and vice versa, morphological pre-conditions for occlusion of thrombosis and blood vessels that will become significant part of strategy on treatment of wall structure stability and post-operation treatment.