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Emerging drugs for the treatment of irritability associated with autism spectrum disorder.
Expert Opin Emerg Drugs
March 2024
Psychiatric Research Center, Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Introduction: Autism spectrum disorder (ASD) is an early-onset disorder with a prevalence of 1% among children and reported disability-adjusted life years of 4.31 million. Irritability is a challenging behavior associated with ASD, for which medication development has lagged.
View Article and Find Full Text PDFCalciphylaxis, beware the ophthalmic mimic: A case series.
Clin Nephrol Case Stud
December 2023
Department of Ophthalmology, and.
Article Synopsis
- This text discusses two rare cases of calciphylaxis that showed eye-related issues without typical skin symptoms, aiming to increase awareness of the condition.
- The cases include a 76-year-old woman with kidney failure and anterior ischemic optic neuropathy (AION), and a 44-year-old man on dialysis with AION and central retinal artery occlusion (CRAO).
- It emphasizes the importance of recognizing calciphylaxis in kidney patients with eye problems, and suggests a temporal artery biopsy for accurate diagnosis to prevent unnecessary treatments like steroids.
A Systematic Review and Bayesian Network Meta-Analysis of Medical Therapies for Lichen Planopilaris.
Dermatology
August 2024
Montefrío Health Center, Andalusian Health Service, Granada, Spain.
Background: Lichen planopilaris (LPP) is a primary chronic lymphocytic cutaneous disorder that selectively destroys the hair follicles, resulting in scarring alopecia. Unfortunately, current available treatments are not fully effective to stop hair loss, and the level of evidence for medical interventions is weak.
Objectives: The present article aimed to determine the efficacy of the different medical interventions in LPP through a network meta-analysis (NMA).
In severe alcohol-related hepatitis, acute kidney injury is prevalent, associated with mortality independent of liver disease severity, and can be predicted using IL-8 and micro-RNAs.
Aliment Pharmacol Ther
December 2023
Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Background: The prevalence, prediction and impact of acute kidney injury (AKI) in alcohol-related hepatitis (AH) is uncertain.
Aims: We aimed to determine AKI incidence; association with mortality; evaluate serum biomarkers and the modifying effects of prednisolone and pentoxifylline in the largest AH cohort to date.
Methods: Participants in the Steroids or Pentoxifylline for Alcoholic Hepatitis trial with day zero (D0) creatinine available were included.
Granulocyte colony-stimulating factor with or without stem or progenitor cell or growth factors infusion for people with compensated or decompensated advanced chronic liver disease.
Cochrane Database Syst Rev
June 2023
Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy.
Background: Advanced chronic liver disease is characterised by a long compensated phase followed by a rapidly progressive 'decompensated' phase, which is marked by the development of complications of portal hypertension and liver dysfunction. Advanced chronic liver disease is considered responsible for more than one million deaths annually worldwide. No treatment is available to specifically target fibrosis and cirrhosis; liver transplantation remains the only curative option.
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