AI Article Synopsis
- A new method for detecting hemoglobin concentration in blood is introduced, using photothermal angular light scattering for quick and chemical-free results.
- Hemoglobin's iron content absorbs 532-nm light, producing heat that changes the blood's refractive index, which is then measured to quantify hemoglobin levels.
- The method can detect hemoglobin concentrations from 0.35 to 17.9 g/dL with a high correlation to traditional hematology analyzers, achieving a precision of 0.63 g/dL.
Article Abstract
We present a direct, rapid and chemical-free detection method for hemoglobin concentration ([Hb]), based on photothermal angular light scattering. The iron oxides contained in hemoglobin molecules exhibit high absorption of 532-nm light and generate heat under the illumination of 532-nm light, which subsequently alters the refractive index of blood. We measured this photothermal change in refractive index by employing angular light scattering spectroscopy with the goal of quantifying [Hb] in blood samples. Highly sensitive [Hb] measurement of blood samples was performed by monitoring the shifts in angularly dispersed scattering patterns from the blood-loaded microcapillary tubes. Our system measured [Hb] over the range of 0.35-17.9 g/dL with a detection limit of ~0.12 g/dL. Our sensor was characterized by excellent correlation with a reference hematology analyzer (r>0.96), and yielded a precision of 0.63 g/dL for a blood sample of 9.0 g/dL.
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| http://dx.doi.org/10.1016/j.bios.2015.06.066 | DOI Listing |
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