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| http://dx.doi.org/10.11604/pamj.2015.20.311.6434 | DOI Listing |
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Differential expression of metabolic enzymes in testicular germ cell tumors: The impact of glycolytic metabolism in embryonal carcinoma histotype.
Andrology
December 2024
Cancer Biology and Epigenetics Group, Research Center of IPO Porto (CIIPOP)/CI-IPOP@RISE (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Center Raquel Seruca (Porto.CCC Raquel Seruca), Porto, Portugal.
Background: Testicular germ cell tumors are the most common solid malignancies in young men, with increasing incidence worldwide. Broadly classified into seminomas and non-seminomas, they exhibit distinct biological behaviors and responses to treatment. Although metabolic reprogramming is an acknowledged cancer hallmark, metabolic pathways in testicular germ cell tumors remain poorly understood.
View Article and Find Full Text PDFExploring the interplay between inflammation and male fertility.
FEBS J
December 2024
UMIB - Unit for Multidisciplinary Research in Biomedicine, ICBAS - School of Medicine and Biomedical Sciences, University of Porto, Portugal.
Male fertility results from a complex interplay of physiological, environmental, and genetic factors. It is conditioned by the properly developed anatomy of the reproductive system, hormonal regulation balance, and the interplay between different cell populations that sustain an appropriate and functional environment in the testes. Unfortunately, the mechanisms sustaining male fertility are not flawless and their perturbation can lead to infertility.
View Article and Find Full Text PDFMethyl Paraben Affects Porcine Oocyte Maturation Through Mitochondrial Dysfunction.
Biomolecules
November 2024
Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, School of Pharmacy and Food Engineering, Wuyi University, Jiangmen 529000, China.
Parabens are widely used in various industries, which are including chemical, pharmaceutical, food, cosmetic, and plastic processing industries. Among these, methyl paraben (MP) serves as an antimicrobial preservative in processed foods, pharmaceuticals, and cosmetics, and it is particularly detected in baby care products. Studies indicate that MP functions as an endocrine-disrupting compound with estrogenic properties, negatively affecting mitochondrial bioenergetics and antioxidant activity in testicular germ cells.
View Article and Find Full Text PDFThe prevalence of solid tumors and hematologic malignancies among patients with Down syndrome: A systematic review and meta-analysis.
Crit Rev Oncol Hematol
January 2025
Federal University of Pará, 01 Augusto Corrêa St., Belém 66075-110, Brazil.
Background: Patients with Down syndrome (DS) have a unique genetic and clinical profile that may increase the risk of cancer.
Methods: A literature search on PubMed, Scopus, Web of Science, and the Cochrane databases was conducted, focusing on studies to investigate the prevalence of solid and hematologic tumors in DS.
Results: Fifteen studies were included, encompassing 62,121 individuals with Down syndrome (DS).
How Many Lymph Nodes are Enough in Paratesticular Rhabdomyosarcoma?
J Pediatr Surg
October 2024
Department of Urology, Division of Pediatric Urology, University of Kentucky, Lexington, KY, USA. Electronic address:
Background: Treatment strategies for paratesticular rhabdomyosarcoma (PT RMS) are based on stage, which requires accurate lymph node (LN) evaluation. Previous methodology for determining quantity of LN for negative nodal status is based on LN positivity rates, without accounting for the relationship between LNs or amongst patients. This study aims to quantify the chance of missing involved LNs based on LN yield (LNY) using a previously established methodology in comparison to current recommendations.
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