AI Article Synopsis
- Chromatin remodeling is increasingly recognized as a key factor in abnormal development and cancer over the past ten years.
- While individual complexes have been studied, there hasn't been a comprehensive summary of the different chromatin remodeling families.
- This review introduces these families, highlights their roles in developmental issues and cancer, and explains how they modify chromatin structure.
Article Abstract
Over the past decade, chromatin remodelling emerged as one of the most important causes of both abnormal development and cancer. Although much has been written about one or another of the complexes, no recent concise summary of the chromatin remodelling families as a whole is available. In this short review, we introduce the family members, briefly summarize their role in developmental abnormalities and neoplasia, and outline the different ways in which these families remodel chromatin.
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| http://dx.doi.org/10.1002/path.4585 | DOI Listing |
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