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G2691A and C2491T mutations of factor V gene and pre-disposition to myocardial infarction in Morocco.
Biomed Rep
November 2016
Laboratory of Genetics and Molecular Pathology, Medical School, University Hassan II, Casablanca 22000, Morocco.
Coagulation factor Leiden mutation has been described as a common genetic risk factor for venous thrombosis; however, this mutation was reported to be practically absent in an African population. Recently, a novel non-sense mutation in the gene encoding factor V has been associated with the risk of occurrence of cardio-cerebrovascular diseases such as stroke and venous thrombosis. The aim of the present study was to investigate whether the factor V Leiden (FVL) and C2491T non-sense mutations are associated with the risk of developing myocardial infarction.
View Article and Find Full Text PDFFirst study of C2491T FV mutation with ischaemic stroke risk in Morocco.
J Genet
June 2015
Faculty of Medicine and Pharmacy, Department of Genetic and Molecular Pathology Laboratory (LGPM), Tarek Ibn Ziad, QH, Hassan II University, 9154 Casablanca, Morocco.
First study of the C2491t nonsense mutation frequency in moroccan healthy population.
J Mol Neurosci
October 2013
Laboratory of Human Genetics and Molecular Pathology, Medical School, University Hassan II Casablanca, Casablanca, Morocco,
The mutation FV Leiden (G1691A) is the most common mutation worldwide with a variable allelic frequency between countries. More frequent in the European and Caucasian populations and rare or absent in African native population, the FVL was studied in the Moroccan population (They-They et al. Ann Hum Biol 37(6):767-777, 2010) and is totally absent as reported previously by (Mathonnet et al.
View Article and Find Full Text PDFFive novel mutations in the gene for human blood coagulation factor V associated with type I factor V deficiency.
Blood
July 2001
Department of Clinical Chemistry, University Medical Center, Utrecht, The Netherlands.
Coagulation factor V (FV) plays an important role in maintaining the hemostatic balance in both the formation of thrombin in the procoagulant pathway as well as in the protein C anticoagulant pathway. FV deficiency is a rare bleeding disorder with variable phenotypic expression. Little is known about the molecular basis underlying this disease.
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