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Breaking research silos to achieve equitable precision medicine in rheumatology.
Nat Rev Rheumatol
January 2025
Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC, USA.
Health disparities in rheumatic disease are well established and urgently need addressing. Obstacles to precision medicine equity span both the clinical and the research domains, with a focus placed on structural barriers limiting equitable health care access and inclusivity in research. Less articulated factors include the use of inaccurate population descriptors and the existence of research silos in rheumatology research, which creates a knowledge gap that precludes addressing the health disparities and fulfilling the goals of precision medicine to understand the 'full patient'.
View Article and Find Full Text PDFFederated Learning: Breaking Down Barriers in Global Genomic Research.
Genes (Basel)
December 2024
Genomic Medicine Laboratory UILDM, IRCCS Santa Lucia Foundation, 00179 Rome, Italy.
Recent advancements in Next-Generation Sequencing (NGS) technologies have revolutionized genomic research, presenting unprecedented opportunities for personalized medicine and population genetics. However, issues such as data silos, privacy concerns, and regulatory challenges hinder large-scale data integration and collaboration. Federated Learning (FL) has emerged as a transformative solution, enabling decentralized data analysis while preserving privacy and complying with regulations such as the General Data Protection Regulation (GDPR).
View Article and Find Full Text PDFIt's late, but not too late to transform health systems: a global digital citizen science observatory for local solutions to global problems.
Front Digit Health
November 2024
DEPtH Lab, School of Health Studies, Faculty of Health Sciences, Western University, London, ON, Canada.
A key challenge in monitoring, managing, and mitigating global health crises is the need to coordinate clinical decision-making with systems outside of healthcare. In the 21st century, human engagement with Internet-connected ubiquitous devices generates an enormous amount of big data, which can be used to address complex, intersectoral problems via participatory epidemiology and mHealth approaches that can be operationalized with digital citizen science. These big data - which traditionally exist outside of health systems - are underutilized even though their usage can have significant implications for prediction and prevention of communicable and non-communicable diseases.
View Article and Find Full Text PDFCDC's Core Elements to promote diagnostic excellence.
Diagnosis (Berl)
November 2024
Division of Healthcare Quality Promotion, US Centers for Disease Control and Prevention, Atlanta, GA, USA.
Nearly a decade after the National Academy of Medicine released the "Improving Diagnosis in Health Care" report, diagnostic errors remain common, often leading to physical, psychological, emotional, and financial harm. Despite a robust body of research on potential solutions and next steps, the translation of these efforts to patient care has been limited. Improvement initiatives are still narrowly focused on selective themes such as diagnostic stewardship, preventing overdiagnosis, and enhancing clinical reasoning without comprehensively addressing vulnerable systems and processes surrounding diagnosis.
View Article and Find Full Text PDFLessons Learned From the Implementation of an Integrated Health and Social Care Child and Family Hub - a Case Study.
Int J Integr Care
November 2024
Department of Paediatrics, University of Melbourne, Australia.
Introduction: Childhood adversity is associated with poor physical and mental health outcomes across the lifespan. Integration of health and social care may provide a solution to childhood adversity through practices of better detection and response. There is growing interest in the creation of child and family hubs that integrate health and social care but little literature that describes the development process.
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