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Comparative Analysis of Digital Transcriptomics Between Pre- and Post-Treatment Samples of Patients with Locally Advanced Cervical Cancer: A Preliminary Study.
Curr Issues Mol Biol
October 2024
Institute for Pathology, University Hospital Cologne and Medical Faculty, 50937 Cologne, Germany.
Cervical cancer remains a leading cause of cancer-related deaths in women worldwide, with limited treatment options for advanced stages and therapy-resistant cases. Despite advances in treatment, the variability in the patient response to standard therapies underscores the need for molecular biomarkers to guide personalized treatment strategies. This study aimed to explore the transcriptomic changes associated with the therapeutic response in locally advanced cervical cancer, focusing on 770 immune-related genes.
View Article and Find Full Text PDFEpithelial Antimicrobial Peptide/Protein and Cytokine Expression Profiles Obtained from Nasopharyngeal Swabs of SARS-CoV-2-Infected and Non-Infected Subjects.
Viruses
September 2024
Department of Internal Medicine, Ruhr-University Bochum, 44791 Bochum, Germany.
Immune responses of the epithelia of the upper respiratory tract are likely crucial in early inhibition of the viral replication and finally clearance of SARS-CoV-2. We aimed to compare the expression profiles of antimicrobial peptides/proteins (AMPs) and related cytokines observed in the nasopharynx of SARS-CoV-2-infected patients and non-infected controls and to assess the associations between these parameters and COVID-19 patients' outcomes. We included 45 subjects who had tested positive for SARS-CoV-2 and 22 control subjects who had tested negative for SARS-CoV-2.
View Article and Find Full Text PDFLiquid-liquid phase separation-related genes associated with prognosis, tumor microenvironment characteristics, and tumor cell features in bladder cancer.
Clin Transl Oncol
September 2024
Department of Urology, Urology Research Institute, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.
Objective: This study aimed to explore the Liquid-liquid phase separation (LLPS)-related genes associated with the prognosis of bladder cancer (BCa) and assess the potential application of LLPS-related prognostic signature for predicting prognosis in BCa patients.
Methods: Clinical information and transcriptome data of BCa patients were extracted from the Cancer Genome Atlas-BLCA (TCGA-BLCA) database and the GSE13507 database. Furthermore, 108 BCa patients who received treatment at our institution were subjected to a retrospective analysis.
Prognostic Value of S100 Family mRNA Expression in Hepatocellular Carcinoma.
Turk J Gastroenterol
April 2024
Department of Nephrology, the First Affiliated Hospital of Huzhou Teachers College, the First People's Hospital of Huzhou, Huzhou, Zhejiang, China.
Article Synopsis
- * Through analyses of mRNA expressions in liver cancer, several S100 proteins (like S100PBP, S100A2, and S100A10) were linked to shorter overall survival, while S100A5 was linked to longer survival.
- * Despite identified associations, mutations in S100 genes did not show significant effects on overall or disease-free survival in HCC patients, suggesting the need for further research to validate these findings.
Key genes and immune infiltration patterns and the clinical implications in psoriasis patients.
Skin Res Technol
August 2024
Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, Guangdong, China.
Background: Psoriasis is an immune-mediated skin disease, closely related to immune regulation. The aim was to understand the pathogenesis of psoriasis further, reveal potential therapeutic targets, and provide new clues for its diagnosis, treatment, and prevention.
Materials And Methods: Expression profiling data were obtained from the Gene Expression Omnibus (GEO) database for skin tissues from healthy population and psoriasis patients.
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