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Comparison of Systemic Inflammatory Indices With the Oncotype DX Recurrence Score and the Nottingam Prognostic Index in Early Hormone Receptor Positive Ductal Breast Cancer.
Clin Breast Cancer
December 2024
Faculty of Medicine, Health and Life Science, Swansea University, Wales, United Kingdom.
Background: Adjuvant therapy decisions in hormone receptor positive, HER2 negative breast cancer are evolving. Gene panel testing has reduced the number of patients recommended for chemotherapy by up to two thirds. Identifying low risk genomic cases before testing could represent a significant economic impact.
View Article and Find Full Text PDFHuman-AI collaboration improves adults' oral biomechanical functions: A multi-centre, self-controlled clinical trial.
J Dent
November 2024
Dental Materials Science, Division of Applied Oral Sciences and Community Dental Care, Faculty of Dentistry, The University of Hong Kong, Prince Philip Dental Hospital, 34 Hospital Road, Sai Ying Pun, Hong Kong, Hong Kong SAR, PR China. Electronic address:
Objectives: Maintenance of oral muscle functions is important for survival and communication. Utilizing Artificial Intelligence (AI) as a self-health-management material has shown promise. Here we developed a functional and AI-enabled smartphone e-Oral APP that provided real-time feedback features to let humans collaborate with AI, targeting to improve oral biomechanical and speech functions of adults.
View Article and Find Full Text PDFAnimal and bacterial viruses share conserved mechanisms of immune evasion.
Cell
October 2024
Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02115, USA. Electronic address:
Animal and bacterial cells sense and defend against viral infections using evolutionarily conserved antiviral signaling pathways. Here, we show that viruses overcome host signaling using mechanisms of immune evasion that are directly shared across the eukaryotic and prokaryotic kingdoms of life. Structures of animal poxvirus proteins that inhibit host cGAS-STING signaling demonstrate architectural and catalytic active-site homology shared with bacteriophage Acb1 proteins, which inactivate CBASS anti-phage defense.
View Article and Find Full Text PDFIntegrating multilocus phylogeny and morphological analysis reveals the prevalence of Phytophthora meadii (McRae) associated with abnormal leaf fall disease of Hevea brasiliensis in India.
Fungal Biol
October 2024
Plant Pathology Division, Rubber Research Institute of India, Rubber Board P.O, Kottayam, Kerala, 686009, India. Electronic address:
The Oomycetes fungus Phytophthora spp. which causes Abnormal leaf fall (ALF) disease poses a significant threat as one of the most devastating diseases affecting rubber trees in India. A total of 30 Phytophthora isolates were obtained from ALF-affected samples collected during the Southwest monsoon season of Kerala.
View Article and Find Full Text PDFExhaustive identification and characterization of Colletotrichum siamense and Colletotrichum fructicola as causative agents of circular leaf spot disease of rubber tree (Hevea brasiliensis) in India.
Fungal Biol
August 2024
Rubber Research Institute of India, Kottayam, Kerala, 686009, India. Electronic address:
Article Synopsis
- The rubber tree is an important plant used to make natural rubber and is grown in many countries, including India.
- Recently, rubber trees have been getting a disease called Circular Leaf Spot (CLS), which causes brown spots and yellowing leaves.
- In a study, scientists figured out that two types of fungi, named Colletotrichum siamense and Colletotrichum fructicola, are responsible for this disease in rubber trees in India.
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