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Introduction There are conflicting data on the association between postnatal cytomegalovirus (CMV) infection and growth and cognitive outcome in very preterm infants. The aim of the current study was to systematically evaluate the effect of postnatal CMV infection on growth and cognitive outcome in an unselected, contemporary cohort of very preterm infants. Methods Infants <32 gestational weeks (2011-2018) were screened for postnatal CMV infection.
View Article and Find Full Text PDFCytomegalovirus-associated pancytopenia in a four-month-old infant: a case report.
BMC Infect Dis
November 2024
Pediatric Department, Patan Academy of Health Sciences - School of Medicine, Lagankhel, Lalitpur, 44700, Nepal.
Article Synopsis
- - Cytomegalovirus (CMV) is a common herpes virus that usually causes mild or no symptoms in healthy people but can lead to serious complications in those who are immunocompromised or newborns, causing disabilities.
- - A four-month-old girl presented with decreased feeding and severe anemia; lab tests revealed low blood cell counts and a urine CMV PCR test showed extremely high viral load, indicating CMV-related bone marrow suppression.
- - She was treated with the antiviral drug valganciclovir, resulting in improved blood parameters, highlighting the importance of recognizing CMV infections in cases of anemia or low blood cell counts in infants for better outcomes.
An epigenetic human cytomegalovirus infection score predicts viremia risk in seropositive lung transplant recipients.
Epigenetics
December 2024
Department of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA, USA.
Article Synopsis
- Cytomegalovirus (CMV) infection in solid organ transplant recipients significantly raises the chances of complications such as viremia (viral presence in blood), graft failure, and even death.
- Research shows that solid organ transplant recipients who received organs from CMV-positive donors are at a higher risk of viremia compared to those who received organs from CMV-negative donors.
- A study profiling DNA methylation in transplant candidates found that CMV-positive recipients exhibit an altered immune epigenome, leading to potential biomarkers, like the CMV episcore, which could help predict viremia risk in these patients post-transplant.
Retinal ghost in a patient with Behçet's disease and positive cytomegalovirus PCR in the vitreous sample.
Eur J Ophthalmol
January 2025
The Ocular Immunology and Uveitis Foundation, Waltham, MA, USA.
Article Synopsis
- * Upon seeking a second opinion, her left eye presented symptoms like floaters and a scotoma, leading to further examinations that identified an atrophic lesion and the presence of CMV.
- * The findings emphasize the need to consider infections, especially opportunistic ones, in patients with persistent noninfectious uveitis and underlying conditions.
Postnatal cytomegalovirus infections did not alter amplitude-integrated electroencephalography signals or general movements in preterm infants.
Acta Paediatr
February 2025
Department of Pediatrics II (Neonatology), Medical University of Innsbruck, Innsbruck, Austria.
Aim: Controversy prevails about whether postnatal cytomegalovirus (CMV) infections are associated with adverse neurodevelopmental outcomes. We aimed to investigate whether amplitude-integrated electroencephalography (aEEG) signals and General Movement Assessment (GMA) scores differed in very preterm infants with postnatal CMV infections.
Methods: This was a retrospective single-centre study, conducted at Innsbruck Medical University Hospital, Austria, between February 2011 and November 2018.
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