AI Article Synopsis
- Aging leads to reduced endothelial function, particularly affecting nitric oxide availability and endothelium-dependent hyperpolarizations (EDH), which are further worsened by hypertension.
- The study observed that while WKY rats show reduced EDH-type relaxations with age, SHR rats show an even greater impairment, indicating a more pronounced issue in hypertensive conditions.
- The findings suggest that the reduction in EDH-type relaxation with aging is linked to dysfunction in specific channels (SKCA) and enzymes (Na-K ATPase), and the effect is intensified in hypertensive rats due to aging-related cellular changes.
Article Abstract
Aging is accompanied by endothelial dysfunction due to reduced bioavailability of nitric oxide (NO) and/or reduced endothelium-dependent hyperpolarizations (EDH). This study examines the hypothesis that hypertension aggravates the impairment of EDH-type relaxation due to aging. EDH-type relaxations were studied in superior mesenteric arteries isolated from Wistar Kyoto (WKY) and spontaneously hypertensive (SHR) rats of 12, 36, 60, and 72 weeks of age. EDH-type relaxations in WKY were reduced with aging, and this was associated with an impairment of the function of small-conductance calcium-activated potassium channels (SKC a) and sodium-potassium ATPase (Na-K ATPase). EDH-type relaxation in SHR was smaller than that in WKY arteries, and further reduction occurred with aging. Pharmacological experiments suggested a reduced involvement of SKC a and Na-K ATPase and activation of adenosine monophosphate-activated protein kinase and silent information regulator T1 (sirtuin-1; SIRT1) in mesenteric arteries of 12-week-old SHR. These pharmacological findings suggest that in superior mesenteric arteries of the rat, the reduction in EDH-type relaxation occurs with aging and that such a reduction is exacerbated in hypertension. The latter exacerbation appears to involve proteins associated with the process of cellular senescence and is related to impaired function of SKC a and Na-K ATPase, a phenomenon that is also observed in mesenteric arteries of older normotensive rats.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492766 | PMC |
| http://dx.doi.org/10.1002/prp2.150 | DOI Listing |
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