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Crit Care
February 2021
Department of Medical and Surgical Science, Anesthesia and Intensive Care, Policlinico di Sant'Orsola, Alma Mater, University of Bologna, Bologna, Italy.
Background: Mortality rates for patients with ARDS remain high. We assessed temporal changes in the epidemiology and management of ARDS patients requiring invasive mechanical ventilation in European ICUs. We also investigated the association between ventilatory settings and outcome in these patients.
View Article and Find Full Text PDFVaccines (Basel)
June 2020
St James's Hospital Intensive Care Unit, James's Street, Dublin 8, Ireland.
the role of innate immunity in human sepsis must be fully clarified to identify potential avenues for novel immune adjuvant sepsis therapies. A prospective observational study was performed including patients with sepsis (septic group), infection without sepsis (infection group), and healthy controls (control group) in the setting of acute medical wards and intensive care units in a 1000-bed university hospital. A total of 42 patients with sepsis, 30 patients with infection, and 30 healthy controls were studied.
View Article and Find Full Text PDFPLoS One
March 2020
Department of Intensive Care Medicine, St James's Hospital, Dublin, Ireland.
Objective: The role of Th1 and Th17 lymphocyte responses in human infection and sepsis of elderly patients has yet to be clarified.
Design: A prospective observational study of patients with sepsis, infection only and healthy controls.
Setting: The acute medical wards and intensive care units in a 1000 bed university hospital.
Clin Biochem Rev
August 2018
Retired Head of Biochemistry Department, The Children's Hospital at Westmead, Westmead, NSW 2145, Australia.
Atherosclerosis often begins in childhood or adolescence. Post-mortem studies in children have shown the presence of coronary atheroma, and there are hereditary conditions associated with hyperlipidaemia in childhood which lead to premature cardiovascular disease. Detection of hyperlipidaemia early in life can be crucial in the prevention of premature death from atherosclerosis.
View Article and Find Full Text PDFAnn Transl Med
November 2017
Department of Intensive Care, St James's Hospital Dublin, Dublin, Ireland.
Recent advances in sepsis therapy exclusively involve improvements in supportive care, while sepsis mortality rates remain disturbingly high at 30%. These persistently high sepsis mortality rates arise from the absence of sepsis specific therapies. However with improvements in supportive care, patients with septic shock commonly partially recover from the infection that precipitated their initial illness, yet they frequently succumb to subsequent health care associated infections.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!