The transcription factor forkhead box O1 (FoxO1) plays pleiotropic roles in insulin-mediated glucose and lipid metabolism. In the liver, glucose production is finely controlled by insulin signaling that dampens FoxO1. Two recent studies show that silencing of FoxO1 is also essential for extra-hepatic insulin signaling to maintain glucose homeostasis.
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| http://dx.doi.org/10.1016/j.tem.2015.06.006 | DOI Listing |
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