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Neuropeptide levels in Dercum's disease (adiposis dolorosa).
Reumatismo
July 2012
Department of Clinical Sciences Malmö, Lund University, Plastic and Reconstructive Surgery, Skåne University Hospital, Malmö, Sweden.
Dercum's disease (adiposis dolorosa) is characterised by adiposity and chronic pain in the adipose tissue. It has been proposed that conditions encompassing chronic pain have altered concentrations of neuropeptides involved in pain transmission. The aim of this investigation was to examine whether patients with Dercum's disease have abnormal concentrations of different neuropeptides.
View Article and Find Full Text PDFFreezing of enkephalinergic functions by multiple noxious foci: a source of pain sensitization?
PLoS One
September 2009
Team Pain, INSERM UMRS 975, CNRS UMR 7225, Paris, France.
Background: The functional significance of proenkephalin systems in processing pain remains an open question and indeed is puzzling. For example, a noxious mechanical stimulus does not alter the release of Met-enkephalin-like material (MELM) from segments of the spinal cord related to the stimulated area of the body, but does increase its release from other segments.
Methodology/principal Findings: Here we show that, in the rat, a noxious mechanical stimulus applied to either the right or the left hind paw elicits a marked increase of MELM release during perifusion of either the whole spinal cord or the cervico-trigeminal area.
Maternal deprivation increases vulnerability to morphine dependence and disturbs the enkephalinergic system in adulthood.
J Neurosci
May 2005
Institut National de la Santé et de la Recherche Médicale, U513, Laboratoire de Neurobiologie et Psychiatrie, Université Paris XII, Faculté de Médecine, 94010 Créteil, France.
Maternal deprivation can trigger long-lasting molecular and cellular modifications in brain functions and might facilitate the appearance of pathogenic behaviors. This study focuses on the vulnerability to develop morphine dependence in adult rats that were separated from their mother and littermates for 3 h per day for 14 d after birth and examines the adaptive changes in the enkephalinergic pathways. Place-preference conditioning was observed with 2 mg/kg morphine in deprived rats, whereas 5 mg/kg morphine was necessary to induce conditioning in nondeprived animals.
View Article and Find Full Text PDFImmunohistochemistry, histopathology and ultrastructure of Gasterosteus aculeatus tissues infected with Glugea anomala.
Dis Aquat Organ
March 2004
Department of Biology, University of Ferrara, Via Borsari, 46, 44100 Ferrara, Italy.
Immunohistochemical and histopathological studies were conducted on a population of 3-spined sticklebacks Gasterosteus aculeatus (L.) from Loch Airthrey (Stirling, Scotland) naturally infected with the microsporean Glugea anomala (Moniez 1887). Of the 55 host specimens that were examined, 16 (29.
View Article and Find Full Text PDFSubcutaneous formalin enhances outflow of met-enkephalin- and cholecystokinin-like materials in the rat nucleus accumbens.
Naunyn Schmiedebergs Arch Pharmacol
April 2001
NeuroPsychoPharmacologie Moléculaire, Cellulaire et Fonctionnelle, INSERM U 288, Faculté de Médecine Pitié-Salpêtrière, Paris, France.
Using the microdialysis technique, the present study investigated the effects of a noxious stimulation on the extracellular levels of met-enkephalin and (sulfated octapeptide) cholecystokinin-like materials in the nucleus accumbens of freely moving rats. Injection of 50 microl of 5% formalin into the forepaw produced pain-related behaviours associated with an immediate and sustained (for approximately 2 h) increase (+27%) in the outflow of met-enkephalin-like material within the nucleus accumbens. This treatment also progressively enhanced the local outflow of cholecystokinin-like material that reached 200%-250% of the basal level at the end of the experiment, i.
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