Differential privacy has recently emerged in private statistical data release as one of the strongest privacy guarantees. Releasing synthetic data that mimic original data with Differential privacy provides a promising way for privacy preserving data sharing and analytics while providing a rigorous privacy guarantee. However, to this date there is no open-source tools that allow users to generate differentially private synthetic data, in particular, for high dimensional and large domain data. Most of the existing techniques that generate differentially private histograms or synthetic data only work well for single dimensional or low-dimensional histograms. They become problematic for high dimensional and large domain data due to increased perturbation error and computation complexity. We propose DPSynthesizer, a toolkit for differentially private data synthesization. The core of DPSynthesizer is DPCopula designed for high-dimensional and large-domain data. DPCopula computes a differentially private copula function from which synthetic data can be sampled. Copula functions are used to describe the dependence between multivariate random vectors and allow us to build the multivariate joint distribution using one-dimensional marginal distributions. DPSynthesizer also implements a set of state-of-the-art methods for building differentially private histograms, suitable for low-dimensional data, from which synthetic data can be generated. We will demonstrate the system using DPCopula as well as other methods with various data sets and show the feasibility, utility, and efficiency of various methods.
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http://dx.doi.org/10.14778/2733004.2733059 | DOI Listing |
Mol Biol Rep
January 2025
Medical Sociology and Psychobiology, Department of Health and Physical Activity, University of Potsdam, 14469, Potsdam, Germany.
Background: Depression constitutes a risk factor for osteoporosis, but underlying molecular and cellular mechanisms are not fully understood. MiRNAs influence gene expression and are carried by extracellular vesicles (EV), affecting cell-cell communication.
Aims: (1) Identify the difference in miRNA expression between depressed patients and healthy controls; (2) Analyze associations of these miRNAs with bone turnover markers; (3) Analyze target genes of differentially regulated miRNAs and predict associated pathways regarding depression and bone metabolism.
Genes (Basel)
November 2024
Center for Pathobiochemistry and Genetics, Institute of Medical Genetics, Medical University of Vienna, 1090 Vienna, Austria.
Background/objectives: Nucleolin is a major component of the nucleolus and is involved in various aspects of ribosome biogenesis. However, it is also implicated in non-nucleolar functions such as cell cycle regulation and proliferation, linking it to various pathologic processes. The aim of this study was to use differential gene expression analysis and Weighted Gene Co-expression Network analysis (WGCNA) to identify nucleolin-related regulatory pathways and possible key genes as novel therapeutic targets for cancer, viral infections and other diseases.
View Article and Find Full Text PDFProc Int World Wide Web Conf
May 2024
Emory University, Atlanta, GA, USA.
Graph Neural Networks (GNNs) have achieved great success in learning with graph-structured data. Privacy concerns have also been raised for the trained models which could expose the sensitive information of graphs including both node features and the structure information. In this paper, we aim to achieve node-level differential privacy (DP) for training GNNs so that a node and its edges are protected.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Introduction: Progressive supranuclear palsy (PSP) is a devastating 4R tauopathy affecting motor functions and is often misdiagnosed/underdiagnosed due to a lack of specific biomarkers. Synaptic loss is an eminent feature of tauopathies including PSP. Novel synaptic positron emission tomography tracer UCB-J holds great potential for early diagnosis; however, there is a substantial knowledge gap in terms of the mechanism and the extent and nature of synaptic loss in PSP.
View Article and Find Full Text PDFEntropy (Basel)
November 2024
Department of Electrical and Computer Engineering, University of Arizona, Tucson, AZ 85721, USA.
Causal graph discovery (CGD) is the process of estimating the underlying probabilistic graphical model that represents the joint distribution of features of a dataset. CGD algorithms are broadly classified into two categories: (i) constraint-based algorithms, where the outcome depends on conditional independence (CI) tests, and (ii) score-based algorithms, where the outcome depends on optimized score function. Because sensitive features of observational data are prone to privacy leakage, differential privacy (DP) has been adopted to ensure user privacy in CGD.
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