AI Article Synopsis
- TsTX-I, derived from Tityus serrulatus scorpion venom, triggers seizure-like activity in the central nervous system.
- The study focused on how excitatory amino acids and cytokines, particularly IFN-γ, were involved in this process.
- Results showed that while TsTX-I boosts IFN-γ release, it doesn't affect the levels of excitatory amino acids, suggesting IFN-γ plays a more crucial role in convulsions than glutamate.
Article Abstract
TsTX-I, isolated from Tityus serrulatus scorpion venom, causes epileptic-like discharges when injected into the central nervous system. The involvement of excitatory amino acids and cytokines in this activity was investigated. Our results have demonstrated that TsTX-I increases the release of IFN-γ but does not alter the intracerebral concentration of the excitatory amino acids in rats. Thus, this cytokine seems to be more important in the convulsive process than glutamate.
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| http://dx.doi.org/10.1016/j.toxicon.2015.07.006 | DOI Listing |
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