The analgesic efficacy of 5% of EMLA cream (5 or 10 g) when applied for 24 h periods was evaluated in 5 female and 7 male patients (mean age 69 years, range 50-85 years) with refractory post-herpetic neuralgia (PHN). Mean visual analogue pain intensity scores for all patients were significantly improved 6 h after application (P less than 0.05). In a subgroup of patients with facial PHN receiving EMLA cream, 5 g (n = 4), there were significant improvements in pain intensity scores at 6 h (P less than 0.05). 8 h (P less than 0.01) and 10 h (P less than 0.01) after application. Plasma lignocaine and plasma prilocaine concentrations were well below potentially toxic levels in all patients after application.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0304-3959(89)90044-4 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Efficacy of 4% tetracaine gel and lidocaine-prilocaine cream in reducing local anesthetic injection pain in upper eyelid blepharoplasty: a randomized, single-blinded, controlled trial.
BMC Ophthalmol
December 2024
Department of Ophthalmology, The Second Hospital of Dalian Medical University, Dalian, Liaoning Province, China.
Background: The injection of local anesthetics, an extremely painful procedure, leads to a reduction of patients' acceptance.
Objective: To investigate the efficacy and adverse reactions of 4% tetracaine gel (TG) and lidocaine-prilocaine cream (LPC) on reducing the local anesthetic injection pain for upper eyelid blepharoplasty.
Methods: Sixty participants were equally divided into three groups.
Efficacy of topical anesthetics of lidocaine, benzocaine, and EMLA in reducing pain during inferior alveolar nerve block in schoolchildren: a randomized controlled trial.
BDJ Open
November 2024
Department of Pediatric Dentistry, Damascus University, Damascus, Syrian Arab Republic.
Objectives: This study aimed to evaluate the efficacy of 5% EMLA cream and 8% lidocaine gel in reducing pain during inferior alveolar nerve block (IANB) compared with 20% Benzocaine in children aged 6-10 years.
Materials And Methods: This was a triple-blinded, randomized, parallel-group, active-controlled trial with three arms. 45 children were randomly assigned into 3 groups.
Cerebral Changes Following Carpal Tunnel Syndrome Treated with Guided Plasticity: A Prospective, Randomized, Placebo-Controlled Study.
J Brachial Plex Peripher Nerve Inj
January 2024
Department of Hand Surgery, Skåne University Hospital, Malmö, Sweden.
Compression neuropathy, such as carpal tunnel syndrome (CTS), results in changed afferent nerve signaling, which may result in changes in somatosensory brain areas. The purpose of this study was to assess cerebral changes following unilateral CTS and to assess short-term and long-term cerebral effects of guided plasticity treatment using ipsilateral cutaneous forearm deafferentation. Twenty-four patients with mild-to-moderate unilateral CTS were randomized to treatment with anesthetic cream (EMLA) or placebo.
View Article and Find Full Text PDFTopical Anesthesia in Cutaneous Head and Neck Surgery: A Randomized Controlled Trial.
Otolaryngol Head Neck Surg
January 2025
Department of Otolaryngology, University Hospital Waterford, Waterford, Ireland.
Objective: Cutaneous head and neck surgery can safely and effectively be performed using local anesthetic (LA). However, optimizing pain management during LA administration is paramount for patient comfort and procedural efficacy. The primary objective of this study was to investigate the comparative effectiveness of EMLA cream and ethyl chloride (EC) spray in mitigating pain associated with LA administration in cutaneous head and neck surgery.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!