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| http://dx.doi.org/10.11604/pamj.2015.20.271.6471 | DOI Listing |
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Clinical characteristics and management of reoperation for high jejunal atresia: a retrospective study.
Pediatr Surg Int
January 2025
Department of Neonatology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Objective: To analyze the clinical characteristics and available treatment strategies for reoperation of neonatal high jejunal atresia, and recommend preventive measures to reduce the reoperation rate of high jejunal atresia.
Methods: The clinical data of 16 children with high jejunal atresia who underwent reoperation in the Neonatal Surgery Department at Children's Hospital of Zhejiang University School of Medicine from January 2018 to January 2023 were retrospectively analyzed.
Results: Among the 16 unplanned reoperations, 7 (43.
Dipeptidyl peptidase 4 is a cofactor for porcine epidemic diarrhea virus infection.
Vet Microbiol
February 2025
College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China. Electronic address:
Article Synopsis
- Porcine epidemic diarrhea virus (PEDV) is extremely deadly for neonatal piglets, with a mortality rate that can reach 100%, causing significant economic losses in the pig industry.
- The study identifies dipeptidyl peptidase 4 (DPP4) as a cofactor that enhances PEDV invasion and replication by mapping its expression in various piglet tissues and showing its distribution in intestinal cells.
- Research indicates that inhibiting DPP4 reduces PEDV infection, and experiments suggest that DPP4 and PEDV interact directly, reinforcing the idea that DPP4 plays a crucial role in the virus’s ability to infect pigs.
Unlabelled: Transmesenteric hernia is an internal hernia without a sac caused by a congenital defect of the mesentery. It is a rare cause of intestinal atresia, usually diagnosed intraoperatively, therefore, its prognosis is variable and may be associated with high morbidity and mortality.
Objective: To report a case of transmesenteric hernia with multiple intestinal atresia of late diagnosis.
Retinoic acid-adjuvanted vaccine induces antigen-specific secretory IgA in the gut of newborn piglets.
Vaccine
December 2024
Infectious Disease Immunology, Center for Vaccine Research, SSI, Copenhagen, Denmark. Electronic address:
Mucosal secretory IgA (SIgA) produced by subepithelial plasma cells in the lamina propria is the major antigen-specific defense mechanism against mucosal infections. We investigated if a retinoic acid (RA)-containing adjuvant in parenteral immunization, can induce vaccine-specific SIgA in the jejunal lumen in a dose-dependent manner in neonatal pigs immunized with a Chlamydia hybrid antigen. To accurately quantify SIgA responses in mucosal secretions, an antigen-specific ELISA method with secondary detection of porcine secretory component rather than IgA was developed.
View Article and Find Full Text PDFinfection alters the intestinal mucosa transcriptome in neonatal calves: impacts on epithelial barriers and transcellular transport systems.
Front Cell Infect Microbiol
December 2024
Research Institute for Farm Animal Biology (FBN), Dummerstorf, Germany.
Introduction: is the most prevalent enteric protozoan parasite causing infectious diarrhea in neonatal calves worldwide with a direct negative impact on their health and welfare. This study utilized next-generation sequencing (NGS) to deepen our understanding of intestinal epithelial barriers and transport mechanisms in the pathophysiology of infectious diarrhea in neonatal calves, which could potentially unveil novel solutions for treatment.
Methods: At day 1 of life, male Holstein-Friesian calves were either orally infected (n = 5) or not (control group, n = 5) with oocysts (in-house strain LE-01-Cp-15).
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