Purpose: To characterize a synthetic diamond dosimeter (PTW Freiburg microDiamond 60019) in high dose-per-pulse electron beams produced by an Intra Operative Radiation Therapy (IORT) dedicated accelerator.
Methods: The dosimetric properties of the microDiamond were assessed under 6, 8 and 9 MeV electron beams by a NOVAC11 mobile accelerator (Sordina IORT Technologies S.p.A.). The characterization was carried out with dose-per-pulse ranging from 26 to 105 mGy per pulse. The microDiamond performance was compared with an Advanced Markus ionization chamber and a PTW silicon diode E in terms of dose linearity, percentage depth dose (PDD) curves, beam profiles and output factors.
Results: A good linearity of the microDiamond response was verified in the dose range from 0.2 Gy to 28 Gy. A sensitivity of 1.29 nC/Gy was measured under IORT electron beams, resulting within 1% with respect to the one obtained in reference condition under (60)Co gamma irradiation. PDD measurements were found in agreement with the ones by the reference dosimeters, with differences in R50 values below 0.3 mm. Profile measurements evidenced a high spatial resolution of the microDiamond, slightly worse than the one of the silicon diode. The penumbra widths measured by the microDiamond resulted approximately 0.5 mm larger than the ones by the Silicon diode. Output factors measured by the microDiamond were found within 2% with those obtained by the Advanced Markus down to 3 cm diameter field sizes.
Conclusions: The microDiamond dosimeter was demonstrated to be suitable for precise dosimetry in IORT applications under high dose-per-pulse conditions.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ejmp.2015.06.008 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Contribution of Nuclear Fragmentation to Dose and RBE in Carbon-Ion Radiotherapy.
Radiat Res
January 2025
Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.
Variable relative biological effectiveness (RBE) of carbon radiotherapy may be calculated using several models, including the microdosimetric kinetic model (MKM), stochastic MKM (SMKM), repair-misrepair-fixation (RMF) model, and local effect model I (LEM), which have not been thoroughly compared. In this work, we compared how these four models handle carbon beam fragmentation, providing insight into where model differences arise. Monoenergetic and spread-out Bragg peak carbon beams incident on a water phantom were simulated using Monte Carlo.
View Article and Find Full Text PDFResearch on the Composition and Casting Technology of Bronze Arrowheads Unearthed from the Ruins of the Imperial City of the Minyue Kingdom.
Materials (Basel)
January 2025
School of Civil Engineering and Architecture, Wuyi University, No. 358 Baihua Road, Wuyishan 354300, China.
The ruins of the Imperial City of the Minyue Kingdom were an important site of the Minyue Kingdom during the Han Dynasty. Characteristic bronze arrowheads unearthed from the East Gate, with their exquisite craftsmanship, provide important physical evidence for studying ancient bronze casting technology and the military activities of that time. However, there is still a lack of systematic research on the alloy composition, casting process, and chemical stability of these arrowheads in long-term burial environments.
View Article and Find Full Text PDFVery High-Energy Electron Therapy Toward Clinical Implementation.
Cancers (Basel)
January 2025
Intense Laser Irradiation Laboratory, National Institute of Optics, National Research Council of Italy, 56124 Pisa, Italy.
The use of very high energy electron (VHEE) beams, with energies between 50 and 400 MeV, has drawn considerable interest in radiotherapy due to their deep tissue penetration, sharp beam edges, and low sensitivity to tissue density. VHEE beams can be precisely steered with magnetic components, positioning VHEE therapy as a cost-effective option between photon and proton therapies. However, the clinical implementation of VHEE therapy (VHEET) requires advances in several areas: developing compact, stable, and efficient accelerators; creating sophisticated treatment planning software; and establishing clinically validated protocols.
View Article and Find Full Text PDFFirst-principles study of structural, elastic, electronic, transport properties, and dielectric breakdown of CsTe photocathode.
Sci Rep
January 2025
Accelerator Operations and Technology Division, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM, 87545, USA.
The pursuit to operate photocathodes at high accelerating gradients to increase brightness of electron beams is gaining interests within the accelerator community, particularly for applications such as free electron lasers (FEL) and compact accelerators. Cesium telluride (CsTe) is a widely used photocathode material and it is presumed to offer resilience to higher gradients because of its wider band gap compared to other semiconductors. Despite its advantages, crucial material properties of CsTe remain largely unknown both in theory and experiments.
View Article and Find Full Text PDFAtomically resolved imaging of radiation-sensitive metal-organic frameworks via electron ptychography.
Nat Commun
January 2025
Center for Electron Microscopy, South China University of Technology, Guangzhou, China.
Electron ptychography, recognized as an ideal technique for low-dose imaging, consistently achieves deep sub-angstrom resolution at electron doses of several thousand electrons per square angstrom (e/Å) or higher. Despite its proven efficacy, the application of electron ptychography at even lower doses-necessary for materials highly sensitive to electron beams-raises questions regarding its feasibility and the attainable resolution under such stringent conditions. Herein, we demonstrate the implementation of near-atomic-resolution ( ~ 2 Å) electron ptychography reconstruction at electron doses as low as ~100 e/Å, for metal-organic frameworks (MOFs), which are known for their extreme sensitivity.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!