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Amiodarone-Induced Liver Injury and Cirrhosis. | LitMetric

Amiodarone-Induced Liver Injury and Cirrhosis.

ACG Case Rep J

Division of Gastroenterology, Duke University Medical Center, Durham, NC.

Published: January 2015

AI Article Synopsis

  • An 80-year-old woman initially diagnosed with volume overload related to heart failure was later found to have liver injury caused by amiodarone use.
  • The liver damage resulted in severe tissue damage, including submassive necrosis and bridging fibrosis, indicating early cirrhosis.
  • Notably, the liver tissue showed no signs of steatosis or phospholipidosis, which are commonly associated with amiodarone-induced liver conditions.

Article Abstract

We present a case report of an 80-year-old woman with volume overload thought initially to be secondary to heart failure, but determined to be amiodarone-induced acute and chronic liver injury leading to submassive necrosis and bridging fibrosis consistent with early cirrhosis. Her histopathology was uniquely absent of steatosis and phospholipidosis, which are commonly seen in AIC.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435372PMC
http://dx.doi.org/10.14309/crj.2015.23DOI Listing

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