The immunosuppressive tumor microenvironment (TME) is a major obstacle in cancer immunotherapy. Therefore, it has gained attention as a target site. mRNA emerged as a versatile drug class for cancer therapy. We reported that intratumoral administration of mRNA encoding the fusokine Fβ supports tumor-specific T-cell immunity. This study provides proof of concept of the use of mRNA to modulate the TME.
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| http://dx.doi.org/10.1080/2162402X.2015.1005504 | DOI Listing |
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