We report that CD39-expressing-melanoma cells inhibited both T-cell proliferation and the generation of cytotoxic effectors in an adenosine-dependent manner, and that treatment with a CD39-blocking antibody alleviated tumor-mediated immunosuppression. Thus, blocking CD39 ectonucleotidase may represent a novel immunotherapeutic strategy to restore antitumor immunity.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485743 | PMC |
| http://dx.doi.org/10.1080/2162402X.2014.1003015 | DOI Listing |
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