Hand, foot and mouth disease, that was once considered a disease of cattle, has been emerging as a common human childhood disease in the last few years. It is a viral disease characterized by a brief febrile illness and typical vesicular rashes. In rare cases, patients may also develop neurological complications. This report describes a case of hand, foot and mouth disease, presented with typical clinical features in the South Indian region. Key words:Hand, foot and mouth disease, viral lesions, blisters.
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http://dx.doi.org/10.4317/jced.52031 | DOI Listing |
mBio
January 2025
Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China.
Unlabelled: The KREMEN1 (KRM1) protein is a cellular receptor for multiple enteroviruses that cause hand, foot, and mouth disease (HFMD), including coxsackievirus CVA2, CVA3, CVA4, CVA5, CVA6, CVA10, and CVA12. The molecular basis for the broad recognition of these viruses by the KRM1 receptor remains unclear. Here, we report the indispensable role of the completely conserved VP2 capsid protein residue K140 (designated K2140) in mediating receptor recognition and infection by CVA10 and other KRM1-dependent enteroviruses.
View Article and Find Full Text PDFAust Vet J
January 2025
School of Agricultural, Environmental and Veterinary Science, Charles Sturt University, Wagga Wagga, New South Wales, Australia.
Foot-and-mouth disease (FMD) is a highly infectious transboundary emergency animal disease posing a significant threat to the global economy. Australia strengthened border security following the 2022 FMD outbreak in Indonesia allocating resources to promote biosecurity awareness and engagement. This study qualitatively investigated the impact of this extension on the biosecurity perceptions and practices of sheep producers in New South Wales, Australia.
View Article and Find Full Text PDFRev Panam Salud Publica
January 2025
Centro Panamericano de Fiebre Aftosa Unidad de Salud Pública Veterinaria Organización Panamericana de la Salud Río de Janeiro Brasil Centro Panamericano de Fiebre Aftosa, Unidad de Salud Pública Veterinaria, Organización Panamericana de la Salud, Río de Janeiro, Brasil.
Cystic echinococcosis (CE) is a serious public health problem in South America, one that the Pan American Health Organization (PAHO) has included in its Plan of Action for the Control of Neglected Infectious Diseases. A logical framework for CE control was defined: this includes establishing the objective to be achieved (eradication or elimination as a public health problem) and determining levels of endemicity which serve as a guide for establishing frequencies of intervention (high endemicity, endemic, and low endemicity, according to rates in the different hosts). There are two validated tools for CE control: systematic deworming of dogs using praziquantel (PZQ) and systematic vaccination of sheep with recombinant EG95 protein, or a combination of both tools.
View Article and Find Full Text PDFBats are reservoir hosts for numerous well-known zoonotic viruses, but their broader virus-hosting capacities remain understudied. are an order of enteric viruses known to cause disease across a wide range of mammalian hosts, including Hepatitis A in humans and foot-and-mouth disease in ungulates. Host-switching and recombination drive the diversification of worldwide.
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