Objectives/hypothesis: To assess whether transcanal endoscopic access to the basal turn of the cochlea for cochlear implantation is appropriate.
Study Design: Case series study.
Methods: We reviewed 100 consecutive computed tomographic studies of the sinuses and temporal bone in our institution. We excluded studies that demonstrated evidence of congenital anomalies, chronic ear disease, or inadequate visualization of the cochlea. On axial sections, the angles of the basal turn of the cochlea and of the ear canal in reference to the sagittal plane were recorded as a function of age.
Results: Eighty-four studies were included and 16 were excluded. There was significant variability in the relationship between the ear canal and the basal turn of the cochlea in reference to the sagittal plane. A clear majority of images demonstrated the basal turn of the cochlea to align with a more posterior angle than that of the ear canal.
Conclusion: The trajectory provided by posterior tympanotomy aligns more favorably with the basal turn of the cochlea than transcanal access. Endoscopic technique, primarily an ear canal intervention, may not be useful in cochlear implant surgery.
Level Of Evidence: 4. Laryngoscope, 126:689-692, 2016.
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http://dx.doi.org/10.1002/lary.25462 | DOI Listing |
Genes (Basel)
December 2024
Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China.
Background: Hypoxia triggers stress, leading to significant alterations in gene expression patterns, which in turn affect fish's growth and development. Real-time quantitative PCR (RT-qPCR) is a pivotal technique for assessing changes in gene expression. However, its accuracy is highly contingent upon the stable expression of reference genes.
View Article and Find Full Text PDFCell Rep
January 2025
Lendület Thalamus Research Group, HUN-REN Institute of Experimental Medicine, 1083 Budapest, Hungary. Electronic address:
Movement and locomotion are controlled by large neuronal circuits like the cortex-basal ganglia (BG)-thalamus loop. Besides the inhibitory thalamic output, the BG directly control movement via specialized connections with the brainstem. Whether other parallel loops with similar logic exist is presently unclear.
View Article and Find Full Text PDFDev Dyn
January 2025
Department of Human Anatomy, College of Basic Medical Sciences, Jilin University, Changchun, China.
Background: Previous studies with Gfi1-mutated lines have shown that Gfi1 is essential for hair cell maturation and survival.
Results: We analyzed the phenotype of another Gfi1-mutated line Gfi1 in the inner ears of neonates at P5-7 and found that the cochlea phenotypically differed from the vestibule in the Gfi1 mouse. Specifically, there was a marked reduction in hair cells in the cochlea, which was characterized by greater reductions in the outer hair cells but far less reductions (mainly in the basal turn) in the inner hair cells, whereas the vestibular hair cells remained unaffected.
FEBS J
January 2025
Rudolf Schönheimer Institute of Biochemistry, Medical Faculty, Leipzig University, Germany.
Succinate is a pivotal tricarboxylic acid cycle metabolite but also specifically activates the G- and G-coupled succinate receptor 1 (SUCNR1). Contradictory roles of succinate and succinate-SUCNR1 signaling include reports about its anti- or pro-inflammatory effects. The link between cellular metabolism and localization-dependent SUCNR1 signaling qualifies as a potential cause for the reported conflicts.
View Article and Find Full Text PDFbioRxiv
January 2025
Department of Cell and Developmental Biology, School of Biological Sciences, University of California, San Diego, La Jolla, CA, 92093, USA.
Cardiac chambers emerge from a heart tube that balloons and bends to create expanded ventricular and atrial structures, each containing a convex outer curvature (OC) and a recessed inner curvature (IC). A comprehensive understanding of the cellular and molecular mechanisms underlying the formation of these characteristic curvatures remains lacking. Here, we demonstrate in zebrafish that the initially similar populations of OC and IC ventricular cardiomyocytes diverge in the organization of their actomyosin cytoskeleton and subsequently acquire distinct OC and IC cell shapes.
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