A physical macromodel of the erythrocyte membrane was constructed to investigate the effect of intrinsic membrane precurvature on a unique non-isotropic, composite material that dissipated shear energy but stored bending energy. The intrinsic precurvature of the material could be modified from strong positive precurvature through neutral to strong negative precurvature. A spherical shell constructed of the negatively precurved variant of this non-isotropic material spontaneously assumed the characteristic shape of the echinocyte I.
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| http://dx.doi.org/10.1016/s0022-5193(89)80127-4 | DOI Listing |
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