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Spinal accessory nerve transfer for shoulder abduction has no benefit over supraclavicular exploration and nerve grafting in brachial plexus birth injury: a systematic review.
Front Pediatr
December 2024
Department of Clinical Sciences, Umeå University, Umeå, Sweden.
Introduction: Brachial plexus birth injury (BPBI) has an incidence of 0.9 per 1,000 live births in the population. Techniques for repair classically include supraclavicular exploration and nerve grafting (SENG) and more recently nerve transfer, namely of the spinal accessory nerve (SAN) to the suprascapular nerve (SSN) to improve functional outcomes such as glenohumeral abduction and external rotation.
View Article and Find Full Text PDFSelective Muscle Involvement in Amyotrophic Lateral Sclerosis: Evidence Inferred from the Point of Motor Unit Firing Rates.
Noro Psikiyatr Ars
November 2024
Istanbul University, Istanbul Faculty of Medicine, Department of Neurology and Clinical Neurophysiology, Istanbul, Türkiye.
Introduction: The aim of the study is to determine the role of upper motor neuron (UMN) or lower motor neuron (LMN) dysfunction as the primary initiator of distal-proximal and lateral-medial gradients of muscle involvement in amyotrophic lateral sclerosis (ALS).
Methods: Concentric needle electromyography recordings were performed in deltoid, abductor digiti minimi, and first dorsal interosseous (FDI) muscles in patients with ALS and controls during slight voluntary contraction needed to activate two motor units (MU). Five motor unit potential (MUP) pairs were recorded from each muscle.
Introduction: Our objective is to study the relationship between armed conflict injuries and pain and the treatments that have been applied to Ukrainian injured soldiers in our hospital.
Methods: We performed an observational study of a sample of 91 injured soldiers. The metrics we selected for the study included time from injury, length of stay, diagnosis, treatment, type and intensity of pain and questionnaires about pain and quality of life for the group of amputees.
Exercise your graft - An important lesson for cell replacement therapy for Parkinson's disease.
Exp Neurol
December 2024
Sanford Consortium for Regenerative Medicine, La Jolla, CA 92037, USA; Sanford Burnham Prebys Medical Discovery Institute, Center for Stem Cells & Regenerative Medicine, La Jolla, CA 92037, USA.
Article Synopsis
- Parkinson's disease (PD) is a chronic and currently incurable illness affecting millions, leading to increased interest in using pluripotent stem cells for cell replacement therapy to restore lost neurons.
- Despite advancements in therapy, challenges persist in effectively connecting these new neurons to the existing brain circuits, but combining cell therapy with physical activity may enhance these connections.
- Exercise, such as treadmill workouts, has been shown to improve motor and cognitive functions in PD patients, enabling them to relearn movements and enhance their neural circuit connections for better overall functioning.
Preferential motor reinnervation is modulated by both repair site and distal nerve environments.
Exp Neurol
November 2024
Department of Orthopaedic Surgery, Johns Hopkins University, 601 N Caroline St, Baltimore, MD 21287, United States of America; Department of Neurology, Johns Hopkins University, 855 N Wolfe St, Baltimore, MD 21287, United States of America. Electronic address:
To restore function after nerve injury, axons must regenerate from the injury site to the periphery, then reinnervate appropriate end organs when they arrive. Only 10 % of adults who suffer nerve injury will regain normal function, often because axons regenerate to functionally inappropriate targets (Brushart, 2011). The peripheral destination of these axons is largely determined by the pathways they enter at the site of nerve repair.
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