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Effect of infection on immunotherapy for gastrointestinal cancer: a narrative review.
Immunotherapy
March 2025
Department of Medical Oncology, Metaxa Cancer Hospital of Piraeus, Piraeus, Greece.
Immunotherapy for gastrointestinal cancers has elicited considerable amount of attention as a viable therapeutic option for several cancer types. Gut microbiome as a whole plays a critical role in shaping immune responses and influencing cancer progression. Recent evidence suggests that (), may influence immunotherapy efficacy by modulating the tumor microenvironment.
View Article and Find Full Text PDFReactor for Photocatalytic Hydrogen Production from Water.
ChemSusChem
March 2025
Shanghai Jiao Tong University, Department of Instrument Science and Engineering, No. 800 Dongchuan Road, 200240, Shanghai, CHINA.
Solar-energy-driven photocatalytic water (H2O) splitting converts solar energy into a high-valuable chemical, i.e. hydrogen (H2), and is thereby a promising technique for achieving a sustainable society.
View Article and Find Full Text PDFCurrent Biomarkers of IgA Nephropathy.
Semin Nephrol
March 2025
Department of Medicine, Division of Nephrology, Stanford University, Stanford, CA, USA. Electronic address:
IgA nephropathy (IgAN) is the most prevalent primary glomerular disease and has been recognized to carry a poor prognosis. It is therefore critical to identify the patients that will progress to ESKD and start treatments early. The current gold standard for diagnosis remains kidney biopsy.
View Article and Find Full Text PDFThe Genetics of IgA Nephropathy: Implications for Future Therapies.
Semin Nephrol
March 2025
Renal Division, Peking University First Hospital, Beijing, People's Republic of China; Kidney Genetics Center, Peking University Institute of Nephrology, Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, People's Republic of China; Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, People's Republic of China; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, People's Republic of China. Electronic address:
IgA nephropathy (IgAN), the most prevalent primary glomerulonephritis worldwide, carries a considerable lifetime risk of kidney failure. The etiology of IgAN, however, remains incompletely understood, and effective treatment is lacking. Although the multihit model effectively identifies key steps in IgAN development and, to date, provides the best description of IgAN pathogenesis, it remains under development to fully capture the complexity of immune system dysregulation.
View Article and Find Full Text PDFEmerging Biochemical and Immunologic Mechanisms in the Pathogenesis of IgA Nephropathy.
Semin Nephrol
March 2025
Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL.
IgA nephropathy is a mesangioproliferative glomerular disease with significant morbidity and mortality. Most patients with IgA nephropathy develop kidney failure in their lifetime, reducing their life expectancy by a decade. Since its first description in 1968, it has been established that kidneys of IgA nephropathy patients are injured as "innocent bystanders" by nephritogenic IgA1-containing immune complexes.
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