A 52 year-old male farmer was admitted to our hospital because of cough, sputum and dyspnea on exertion. Chest X-ray showed pulmonary edema and arterial blood gas analysis showed hypoxemia. Silo-fillers' disease was diagnosed because he had allegedly inhaled yellowish gas in the silo. The day following steroid therapy, symptoms and pulmonary edema improved. Silo-fillers' disease is chemical pneumonitis due to exposure to the oxides of nitrogen which are produced in silos. Although reported cases of silo-fillers' disease in Japan are rare it should be kept in mind in areas involved with dairy farming.
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Ulster Med J
January 2021
The History Committee, Institute of Biomedical Science, 12 Coldbath Square, London EC1R 5HL, United Kingdom.
Historically, the weighing out and manipulation of dangerous chemicals frequently occurred without adequate protection from inhalation or accidental ingestion. The use of gloves, eye protection using goggles, masks or visors was scant. From Canary Girls and chimney sweeps to miners, stone cutters and silo fillers, these are classic exemplars of the subtle (and in some cases not so subtle) effects that substances, environments and practices can have on individual health.
View Article and Find Full Text PDFNanomaterials (Basel)
March 2020
Department of Advanced Convergence Technology, and Research Institute of Advanced Convergence Technology, Korea Polytechnic University, 237 Sangidaehak-ro, Siheung-si 15073, Korea.
Prolonged exposure to NO can cause lung tissue inflammation, bronchiolitis fibrosa obliterans, and silo filler's disease. In recent years, nanostructured semiconducting metal oxides have been widely used to fabricate gas sensors because of their unique structure and surface-to-volume ratio compared to layered materials. In particular, the different morphologies of ZnO-based nanostructures significantly affect the detection property of NO gas sensors.
View Article and Find Full Text PDFJ Emerg Med
August 2019
Department of Emergency Medicine, Hennepin Healthcare, Minneapolis, Minnesota; Minnesota Poison Control, Hennepin Healthcare, Minneapolis, Minnesota.
Background: Nitrogen dioxide (NO) is a pulmonary irritant produced as a byproduct of bacterial anaerobic metabolism of organic materials, and is also produced as a byproduct of explosive detonations. Significant NO exposure results in free-radical-induced pulmonary injury that may be delayed up to 3-30 h after exposure and can progress to acute respiratory distress syndrome (ARDS) and death. Here we present a case series of 3 patients with dose-dependent pulmonary injury consistent with NO inhalation following exposure to fumes from detonation of an ammonium nitrate/nitromethane (ANNM) explosive device.
View Article and Find Full Text PDFJ Agromedicine
January 2020
Pulmonary Medicine, Marshfield Clinic, Marshfield, Wisconsin, USA.
Silo-filler's disease, a life-threatening condition from exposure to silage gas in recently filled silos, has been known for over 5 decades now. However, farm workers remain exposed to this preventable condition. We describe the index presentations and subsequent changes among 19 patients managed within our health system over a 61-year period and highlight the need for ongoing education on minimizing exposure to silo gas.
View Article and Find Full Text PDFJ Occup Environ Med
May 2013
College of Public Health, University of South Florida, Health Sciences Center, Tampa, FL, USA.
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