AI Article Synopsis
- * The study employed a lentivirus shRNA approach to significantly inhibit RPS24 gene expression in colon cancer cells (HCT116 and HT-29), leading to reduced cell proliferation, migration, and growth.
- * Findings suggest that RPS24 is crucial for colon cancer progression, indicating it could serve as a potential biomarker for diagnosing and treating this type of cancer.
Article Abstract
Besides new proteins synthesis, ribosomal protein has a role in extra-ribosomal functions, which are related to many diseases, such as Diamond-Blackfan anemia, hypoplasia, and cell apoptosis. However, the importance of RPS24 in human colon cancer is largely unknown. In this study, RPS24 gene expression was significantly inhibited in human colon cancer HCT116 and HT-29 cells using a lentivirus shRNA approach. Knockdown of RPS24 expression significantly inhibited cell proliferation, colony formation, cell migration and arrested cell in S phase. The results demonstrated for the first time that RPS24 gene had a critical role in human colon cancer. Therefore, our findings indicated that RPS24 gene may be a promising biomarker for therapy in human colon cancer and may have a potential application in the diagnosis or treatment of human colon cancer.
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| http://dx.doi.org/10.1016/j.gene.2015.06.084 | DOI Listing |
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