AI Article Synopsis
- The study explores the recurrence rates of eosinophilic-type chronic rhinosinusitis with nasal polyps (CRSwNP) after surgery, comparing the effects of post-operative treatment with local nasal steroids versus local nasal and oral steroids.
- Results showed no significant difference in overall recurrence rates between the two treatment groups, but patients with asthma or aspirin sensitivity treated with both local and oral steroids had notably lower recurrence rates.
- The findings suggest that further investigation into the effectiveness of combined steroid treatments for specific patient groups is necessary, especially in larger studies.
Article Abstract
Conclusions: The preliminary finding of significantly lower eosinophilic-type CRSwNP recurrence rates in patients with associated asthma or ASA intolerance treated post-operatively with local nasal and oral steroids warrants further investigation in larger, prospective series.
Objective: A high recurrence rate after functional endoscopic sinus surgery (FESS) has been widely reported in patients with eosinophilic-type chronic rhinosinusitis with nasal polyps (CRSwNP). This study compared the influence of two post-operative medical treatments - local nasal steroids alone vs local nasal and oral steroids - on the recurrence of eosinophilic-type CRSwNP.
Method: Between January 2009-December 2010, 32 patients with eosinophilic-type CRSwNP received local steroid nasal therapy after FESS (Group A); from January 2011 onwards, another 28 patients were treated post-operatively with the same nasal treatment plus two cycles a year of oral steroids (Group B). All patients in both groups had a follow-up of at least 36 months.
Results: Groups A and B did not differ significantly in recurrence rate (31.25% vs 32.14%, p = 1) or disease-free interval (p = 0.91), but Group B patients who were asthmatic or ASA-intolerant had a significantly lower recurrence rate than Group A patients with asthma or ASA intolerance (p = 0.04 and p = 0.004, respectively).
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| http://dx.doi.org/10.3109/00016489.2015.1063784 | DOI Listing |
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