Toxic epidermal necrolysis or Lyell's syndrome is a rare entity with strong compromise of immune system. It is a hypersensitivity reaction secondary to the use of specific drugs and other triggers. Erythematous lesions of bullous aspect characterize the clinical picture affecting all layers of the skin, scaly and widespread in distribution and progression. Sometimes life threatening, generate a severe inflammatory and systemic reaction with multiple organ dysfunction. Treatment encompasses three objectives: identification and suspension of triggers, general clinical support and therapy to the skin lesions. Immune therapy is controversial and not supported by solid scientific evidence. We report a case that summarizes all aspects of this potentially lethal disease.
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