AI Article Synopsis
- Fat-associated lymphoid clusters (FALCs) are specialized immune tissues found in areas with visceral fat, notably abundant in the pericardium.* -
- FALCs play a crucial role in maintaining B-1 cell presence in the peritoneal cavity and enhance B cell activities like proliferation and differentiation during immune challenges through the expression of the chemokine CXCL13.* -
- The formation of FALCs is triggered by inflammation, which recruits myeloid cells and requires natural killer T cells for effective development, ultimately aiding in the immune response coordination.*
Article Abstract
Fat-associated lymphoid clusters (FALCs) are a type of lymphoid tissue associated with visceral fat. Here we found that the distribution of FALCs was heterogeneous, with the pericardium containing large numbers of these clusters. FALCs contributed to the retention of B-1 cells in the peritoneal cavity through high expression of the chemokine CXCL13, and they supported B cell proliferation and germinal center differentiation during peritoneal immunological challenges. FALC formation was induced by inflammation, which triggered the recruitment of myeloid cells that expressed tumor-necrosis factor (TNF) necessary for signaling via the TNF receptors in stromal cells. Natural killer T cells (NKT cells) restricted by the antigen-presenting molecule CD1d were likewise required for the inducible formation of FALCs. Thus, FALCs supported and coordinated the activation of innate B cells and T cells during serosal immune responses.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512620 | PMC |
| http://dx.doi.org/10.1038/ni.3215 | DOI Listing |
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