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| http://dx.doi.org/10.1111/mpp.12268 | DOI Listing |
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Geographic origin and evolution of dengue virus serotypes 1 and 3 circulating in Africa.
Virus Evol
December 2024
Department of Epidemiology and Population Health, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, United States.
Despite the increasing burden of dengue in Kenya and Africa, the introduction and expansion of the virus in the region remain poorly understood. The objective of this study is to examine the genetic diversity and evolutionary histories of dengue virus (DENV) serotypes 1 and 3 in Kenya and contextualize their circulation within circulation dynamics in the broader African region. Viral RNA was extracted from samples collected from a cohort of febrile patients recruited at clinical sites in Kenya from 2013 to 2022.
View Article and Find Full Text PDFConnectome-based biophysical models of pathological protein spreading in neurodegenerative diseases.
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Research Center for Social Computing and Information Retrieval, Harbin Institute of Technology, Harbin, China.
Neurodegenerative diseases are a group of disorders characterized by progressive degeneration or death of neurons. The complexity of clinical symptoms and irreversibility of disease progression significantly affects individual lives, leading to premature mortality. The prevalence of neurodegenerative diseases keeps increasing, yet the specific pathogenic mechanisms remain incompletely understood and effective treatment strategies are lacking.
View Article and Find Full Text PDFDeepFocus: a transnasal approach for optimized deep brain stimulation of reward circuit nodes.
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Department of Electrical and Computer Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, Pennsylvania, 15213-3815, UNITED STATES.
Objective: Transcranial electrical stimulation (TES) is an effective technique to modulate brain activity and treat diseases. However, TES is primarily used to stimulate superficial brain regions and is unable to reach deeper targets. The spread of injected currents in the head is affected by volume conduction and the additional spreading of currents as they move through head layers with different conductivities, as is discussed in [1].
View Article and Find Full Text PDFUnlabelled: is an emergent fungal pathogen of significant interest for molecular research because of its unique nosocomial persistence, high stress tolerance and common multidrug resistance. To investigate the molecular mechanisms of these or other phenotypes, a handful of CRISPR-Cas9 based allele editing tools have been optimized for . Nonetheless, allele editing in this species remains a significant challenge, and different systems have different advantages and disadvantages.
View Article and Find Full Text PDFSocioeconomic and Environmental Impacts of Plantations in Ethiopia: An Evaluation of Benefits, Challenges, and Sustainable Practices.
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Department of Forestry and Climate Change, Injibara University, Injbara, Ethiopia.
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