5'-Ether derivatives of the potent adenosine agonist N-cyclopentyladenosine (CPA) were designed as "caged" ligands for the activation of A-adenosine receptors following photolysis. The synthesis involved a 2',3'-diol protection scheme using the acid labile ethoxymethynyl group. Generation of CPA was demonstrated chromatographically and in a bioassay measuring the inhibition of synaptic potentials in the rat hippocampus.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489149 | PMC |
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