Background: Increasing the value of health care delivery is a national priority, and providers face growing pressure to reduce cost while improving quality. Ample opportunity exists to increase efficiency and quality simultaneously through the application of systems engineering science.
Objective: We examined the hypothesis that Lean-based reorganization of laboratory process flow would improve laboratory turnaround times (TAT) and reduce waste in the system.
Methods: This study was a prospective, before-after analysis of laboratory process improvement in a teaching hospital emergency department (ED). The intervention included a reorganization of laboratory sample flow based in systems engineering science and Lean methodologies, with no additional resources. The primary outcome was the median TAT from sample collection to result for 6 tests previously performed in an ED kiosk.
Results: After the intervention, median laboratory TAT decreased across most tests. The greatest decreases were found in "reflex tests" performed after an initial screening test: troponin T TAT was reduced by 33 minutes (86 to 53 minutes; 99% confidence interval, 30-35 minutes) and urine sedimentation TAT by 88 minutes (117 to 29 minutes; 99% confidence interval, 87-90 minutes). In addition, troponin I TAT was reduced by 12 minutes, urinalysis by 9 minutes, and urine human chorionic gonadotropin by 10 minutes. Microbiology rapid testing TAT, a "control," did not change.
Conclusions: In this study, Lean-based reorganization of laboratory process flow significantly increased process efficiency. Broader application of systems engineering science might further improve health care quality and capacity while reducing waste and cost.
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http://dx.doi.org/10.1016/j.ajem.2015.06.013 | DOI Listing |
Philos Trans A Math Phys Eng Sci
December 2024
Department of Physics, University of Strathclyde, John Anderson Building, 107 Rottenrow, Glasgow G4 0NG, UK.
Quantum retrodiction, in which the state of a quantum system prior to a measurement is assigned based on the results of that measurement, has had a long history and has been used in quantum optics research for decades. Here we summarize the theory and point out some of the more interesting results, before applying the theory to state identification from multiple shots of an experiment. One surprising result is that we show that a photodetector with low quantum efficiency can discriminate between photonic states better than a detector with a higher efficiency.
View Article and Find Full Text PDFPhilos Trans A Math Phys Eng Sci
December 2024
School of Physics, Engineering and Technology, University of York, England, YO10 5DD, UK.
Multipolar quantum optics deals with the interaction of light with matter as a many-body bound system of charged particles where the coupling to electromagnetic fields is in terms of the multipolar electric polarization and magnetization. We describe two transformations applied to the conventional non-relativistic formalism, namely a gauge transformation applied directly to the fields at the Lagrangian stage and a unitary transformation applied to the old Hamiltonian. We show how such transformations lead to the same Power-Zienau-Woolley (PZW) formulation of the quantum electrodynamics (QED) of an overall electrically neutral many-body bound system of charges, including the internal motion as well as the gross dynamics of the centre of mass.
View Article and Find Full Text PDFPhys Chem Chem Phys
December 2024
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, PR China.
Proteins are some of the most important components in living organisms. When nanoparticles enter a living system, they swiftly interact with proteins to produce the so-called "protein corona", which depicts the adsorption of proteins on large nanoparticles (normally tens to hundreds of nanometers). However, the sizes of small nanoparticles (typically, fluorescent nanomaterials such as quantum dots, noble metal nanoclusters, carbon dots, ) are less than 10 nm, which are comparable or even much smaller than those of proteins.
View Article and Find Full Text PDFBiotechnol Bioeng
December 2024
Department of Civil and Environmental Engineering, University of Michigan, Ann Arbor, Michigan, USA.
An open-source modeling platform, called Anaerobic Digestion Model No. 1 Fast (ADM1F), is introduced to achieve fast and numerically stable simulations of anaerobic digestion processes. ADM1F is compatible with an iPython interface to facilitate model configuration, simulation, data analysis, and visualization.
View Article and Find Full Text PDFElife
December 2024
Department of Medical Informatics, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
An unprecedented amount of SARS-CoV-2 data has been accumulated compared with previous infectious diseases, enabling insights into its evolutionary process and more thorough analyses. This study investigates SARS-CoV-2 features as it evolved to evaluate its infectivity. We examined viral sequences and identified the polarity of amino acids in the receptor binding motif (RBM) region.
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