Introduction: Malignant schwannomas or neurofibrosarcomas are rare nerve tumors of unknown etiology. These neoplasms are highly aggressive with a marked propensity for local recurrence and metastatic spread. Their management continues to be a challenge for pathologists and surgeons. Maxillofacial locations are very exceptional. We report the case of a patient with unusual malignant schwannoma of the infratemporal fossa discovered at a late evolving stage.
Case Presentation: A 56-year-old woman, of Moroccan nationality, presented to our hospital in 2013 with a large right-sided hemifacial swelling that had evolved over the previous 4 months, with a limitation of mouth opening, nasal obstruction and episodes of epistaxis. A CT scan and MRI showed a large and invasive tumor occupying her right infratemporal fossa and maxillary sinus, with sphenoidal, ethmoidonasal, nasopharyngeal and intraorbital extension. A nasal endoscopic biopsy was performed. Immunohistochemical examination concluded a diagnosis of malignant schwannoma, and a palliative radiotherapy was decided; however, our patient died 10 days later.
Conclusions: Malignant schwannoma of paranasal sinuses and the anterior skull base is a rare tumor that involves a high rate of local invasion. The prognosis is poorer compared to that occurring in the trunk and extremities.
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http://dx.doi.org/10.1186/s13256-015-0624-6 | DOI Listing |
J Med Life
October 2024
Johns Hopkins Aramco Healthcare, Department of Pathology, Dhahran, Saudi Arabia.
Schwannomas are peripheral nerve sheath tumors that rarely arise from autonomic nerves of the pleural lining. Most often, they present as slow-growing tumors and are asymptomatic. Herein, we describe the case of an elderly male patient who presented with severe chest pain.
View Article and Find Full Text PDFPediatr Dev Pathol
December 2024
Division of Pathology, Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada.
An 11-year-old girl presented with a soft tissue lesion on the dorsal aspect of the left middle finger. Ultrasound imaging demonstrated a 2.8 cm × 0.
View Article and Find Full Text PDFJ Dent (Shiraz)
December 2024
Dept. of Oral and Maxillofacial Pathology and Oral Microbiology, Faculty of Dentistry, Jamia Millia Islamia, New Delhi, India.
Schwannomas are considered benign soft tissue tumors that originate from Schwann cells. Oral Schwannomas are rare and account for only 1% of all Schwannomas. Cellularschwannoma (CS) is a rare histological variant of schwannoma, characterized by high cellularity and cellular atypia.
View Article and Find Full Text PDFEur J Radiol
December 2024
Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Hubei Provincial Clinical Research Center for Precision Radiology & Interventional Medicine, Wuhan 430022, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China. Electronic address:
Objects: To investigate the specific manifestations of neurogenic and non-neurogenic tumors involving peripheral nerves on contrast-enhanced magnetic resonance neurography (CE-MRN) and explore the potential of CE-MRN in aiding differential diagnosis.
Materials And Methods: Twenty-nine patients with neurogenic tumors and 23 with non-neurogenic tumors involving peripheral nerves were enrolled in this study. Both routine MRI and CE-MRN scanning were performed on all subjects.
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