mRNA overexpression of : A novel prognostic factor for pediatric acute lymphoblastic leukemia.

Biomed Rep

Division of Cell, Molecular and Developmental Biology, Department of Biology, Faculty of Science, University of Isfahan, Isfahan 81746-73441, Iran.

Published: May 2015

is a novel molecular marker in leukemia that is highly expressed in patients with acute leukemia. Increased expression levels of are known as poor prognostic factors in adult acute myeloid and lymphoid leukemia. The purpose of the present study was to evaluate the prognostic significance of the gene expression levels in pediatric acute lymphoblastic leukemia (ALL) and its association with . Using reverse transcription-quantitative polymerase chain reaction (RT-qPCR), the mRNA expression levels of and were measured in bone marrow samples of 28 new diagnosed childhood ALL patients and 13 children without cancer. Minimal residual disease (MRD) was measured one year after the initiation of the chemotherapy using the RT-qPCR method. The high level expression of had a significant association with the pre-B-ALL subtype, leukocytosis and positive MRD after one year of treatment in leukemic patients. In addition, a positive correlation between and mRNA expression was shown in this group. In conclusion, to the best of our knowledge, the increase of expression as a poor prognostic factor for childhood ALL is shown for the first time. Additionally, the correlation between and in mRNA expression levels can aid for an improved understanding of the mechanism through which may function in ALL and multidrug resistance.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467268PMC
http://dx.doi.org/10.3892/br.2015.437DOI Listing

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