Analysis of AC3-33 gene expression in multiple organ cancer and adjacent normal tissue by RNA hybridization.

The gene encodes a secretory protein that can inhibit Elk1 transcriptional activity via the ERK1/2 pathway. In the current study, RNA hybridization was used to detect the gene expression in multiple organ cancer and cancer-adjacent normal tissue. The results showed that the expression level of varies across different tissues. exhibited positive expression in squamous cell carcinoma of the esophagus, adenocarcinoma of the rectum, hepatocellular carcinoma, squamous cell carcinoma (SCC) of the lung, cancer-adjacent normal hepatic tissue, clear cell carcinoma of the kidney, invasive ductal carcinoma of the breast, SCC of the uterine cervix and cancer-adjacent normal kidney tissue. Negative expression of was observed in adenocarcinoma of the stomach and colon, cancer-adjacent normal esophageal tissue, cancer-adjacent normal gastric tissue, cancer-adjacent normal colon tissue, cancer-adjacent normal rectal tissue, serous adenocarcinoma of the ovary and cancer-adjacent normal ovarian tissue. However, the expression of in cancer adjacent normal breast tissue was partially positive. In conclusion, the gene does exhibit positive expression in certain carcinomas, which may indicate that has a significant involvement in the development and progression of these carcinomas.