AI Article Synopsis
- - This study explored the link between the EML4-ALK fusion gene and thymidylate synthase (TYMS) expression in non-small cell lung cancer (NSCLC) tissues, analyzing 257 patient samples using quantitative polymerase chain reaction.
- - It found that the EML4-ALK fusion gene was present in 4.28% of cases, being more common in nonsmokers, while TYMS mRNA was expressed in 63.42% of the samples.
- - A significant association was observed where lower levels of TYMS mRNA correlated with the presence of the EML4-ALK fusion gene, suggesting that those patients might benefit from treatment with the chemotherapy drug pemetrexed.
Article Abstract
This study aimed to investigate the association of the mRNA expression of the echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) fusion gene with that of thymidylate synthase (TYMS) in non-small cell lung cancer (NSCLC) tissues. Quantitative polymerase chain reaction was used to detect the expression of EML4-ALK fusion gene and TYMS mRNA in 257 cases of NSCLC. The positive rate of EML4-ALK fusion gene was 4.28% in the NSCLC tissues (11/257), and was higher in nonsmokers than in smokers (P<0.05); TYMS mRNA expression was detected in 63.42% (163/257) of cases. An association of the EML4-ALK fusion gene with TYMS expression was detected; a low expression level of TYMS mRNA was observed more frequently when the EML4-ALK fusion gene was present than when it was not detected (P<0.05). In conclusion, patients positive for the EML4-ALK fusion gene in NSCLC tissues are likely to have a low expression level of TYMS, and may benefit from the first-line chemotherapy drug pemetrexed.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473652 | PMC |
| http://dx.doi.org/10.3892/etm.2015.2372 | DOI Listing |
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