Physiological role of NBCe2 in the regulation of electrolyte transport in the distal nephron.

Am J Physiol Renal Physiol

Department of Cellular/Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska.

Published: September 2015

The electrogenic Na(+)-HCO3 (-) cotransporter 2 (NBCe2) is a newly discovered protein in the distal nephron. Our understanding is minimal regarding its physiological role in renal electrolyte transport. In this mini-review, we summarize the potential function of NBCe2 in the regulation of blood pressure, acid-base, and K(+) and Ca(2+) transport in the distal nephron.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189740PMC
http://dx.doi.org/10.1152/ajprenal.00192.2015DOI Listing

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