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Blood-derived APLP1 extracellular vesicles are potential biomarkers for the early diagnosis of brain diseases.
Sci Adv
January 2025
Department of Biotechnology, College of Life Science, CHA University, Gyeonggi-do 13488, Republic of Korea.
Article Synopsis
- Early detection of neurodegenerative diseases relies on identifying brain-specific biomolecules in blood, and this study explores amyloid precursor-like protein 1 (APLP1) as a new biomarker found in extracellular vesicles (EVs).
- The research confirms that APLP1 EVs in human blood come from the brain, supported by distinct small RNA patterns and the expression of miRNA targets that are highly present in brain tissue.
- Validation using special mouse models (Thy-1 GFP M line) alongside data analysis highlights APLP1 EVs' potential as both diagnostic markers and key players in advancing neurodegenerative disease diagnosis.
Accumulation of alpha-synuclein pathology in the liver exhibits post-translational modifications associated with Parkinson's disease.
iScience
December 2024
Department of Biomedical and Clinical Sciences, Department of Clinical Pathology, Linköping University, Linköping, Sweden.
Accumulating evidence demonstrates that alpha-synuclein (α-syn) pathology associated with Parkinson's disease (PD) is not limited to the brain, as it also appears in a select number of peripheral tissues including the liver. In this study, we identified a number of PD-associated α-syn post-translational modifications in the livers of (Thy-1)-h[A30P] mice, a mouse model of familial PD expressing human α-syn harboring the A30P mutation driven by a neuron-specific promoter. , we also demonstrate that human hepatocytes induce post-translational modifications following α-syn fibrillar (PFF) treatment.
View Article and Find Full Text PDFTo better understand the role of thyroid hormones in regulating the growth of breast epithelial cells and the estrogen-like effects of these hormones, the present study was conducted to investigate the relationship between breast cancer and thyroid autoimmune disorders in southeast Iran women. In this case-control study, in the case group, all newly diagnosed breast cancer pa-tients referred to the oncology clinics in Zahedan city in years 2021‒2022 were studied. The num-ber of participants in each group was represented by 40 breast cancer patients.
View Article and Find Full Text PDF1.25(OH)2D3 decreases PCNA and mTOR expression and alleviates renal injury in Thy-1 nephritis rat model.
PLoS One
December 2024
Department of Nephrology, The First Affiliated Hospital of Shi he zi University, Shihezi City, Xin jiang Province, China.
Objective: This study investigated the role and mechanisms of 1.25(OH)2D3 in proliferative glomerulonephritis and its effect on the regulation of mesangial cells.
Methods: Sixty male SD rats were randomly divided into four groups: control (CG), nephritis (NG), nephritis + 1.
Analysis of cellular effects by continuous exposure AT low concentration of tritium.
Radiat Prot Dosimetry
November 2024
Laboratory of Radiological Disasters and Medical Science, International Research Institute of Disaster Science, Tohoku University, 519-1176 Aramaki-aza-Aoba, Aoba-ku, Sendai 980-0845, Japan.
This study investigated the induction of DNA double-strand breaks (DSBs) in the hTERT-immortalized normal human diploid epithelial cells (RPE1-hTERT) continuously exposed to 6000 Bq/ml of tritiated water (HTO) and organically bound tritium (OBT). The relationship of the DSBs induction with the intracellular amount as well as the localization of tritium was also examined. Tritium-labeled thymidine (3H-Thy) and palmitic acid (3H-PA) were used as OBT.
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