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Molecular characterization of doublesex and Mab-3 (DMRT) gene family in Ctenopharyngodon idella (grass carp).
J Appl Genet
November 2024
Guangxi Key Laboratory of Beibu Gulf Marine Biodiversity Conservation, Beibu Gulf University, Guangxi, 535011, People's Republic of China.
Doublesex and Mab-3 (DMRT) gene family is a diverse group of transcriptional factors crucially involved in sex differentiation and biological processes such as body growth and differentiation in vertebrates. In this study, we analyzed DMRT genes structural characterization and physiochemical properties, and elucidated their functional role as a ligand of different gonadal receptors including androgen (AR), estrogen β (ER-β), estrogen γ (ER-γ), and progesterone (PR). All six genes of the DMRT gene family in grass carp (Ctenopharyngodon Idella Valenciennes, 1844) exhibited an acidic nature.
View Article and Find Full Text PDFDiversity of transactivation regions of DMRT1 in vertebrates.
Mol Biol Rep
October 2024
Department of Bioscience, School of Science, Kitasato University, Sagamihara, 252-0373, Japan.
Background: Doublesex and mab-3 related transcription factor (DMRT) 1, commonly found in all vertebrates, regulates the transcription of genes involved in the masculinization and maintenance of gonadal somatic cells and/or germline cell development. DMRT1 has a DNA-binding domain called the DM domain and a transcription regulatory region. Unlike the former, there is little knowledge about the latter transcription regulatory region.
View Article and Find Full Text PDFPopulation suppression by release of insects carrying a dominant sterile homing gene drive targeting doublesex in Drosophila.
Nat Commun
September 2024
Center for Bioinformatics, School of Life Sciences, Center for Life Sciences, Peking University, Beijing, China.
Article Synopsis
- CRISPR homing gene drives can reduce pest populations by modifying genes related to female fertility, encouraging the transfer of engineered traits through generations.
- The fsRIDL strategy involves releasing transgenic male insects that carry genes causing female infertility to control pest populations.
- The proposed RIDD system combines elements of homing drive and fsRIDL, effectively sterilizing female pests and demonstrating stronger suppression capabilities compared to existing methods, while allowing for controlled population management.
Neurobiology of egg-laying behavior in : neural control of the female reproductive system.
J Neurogenet
September 2024
School of Biological Sciences, University of Oklahoma, Norman, OK, USA.
Egg-laying is one of the key aspects of female reproductive behavior in insects. Egg-laying has been studied since the dawn of as a model organism. The female's internal state, hormones, and external factors, such as nutrition, light, and social environment, affect egg-laying output.
View Article and Find Full Text PDFMedaka () Is Involved in Male Fertility.
Animals (Basel)
August 2024
State Key Laboratory of Mariculture Breeding, Engineering Research Center of the Modern Technology for Eel Industry, Ministry of Education, Jimei University, Xiamen 361021, China.
Research across various species has demonstrated that the doublesex and mab-3-related transcription factor 3 () plays pivotal roles in testis development. However, the precise molecular mechanisms of remain unclear. In this study, we investigated the role of () in testis development using the model organism medaka ().
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