Complete genome sequence of Lactobacillus salivarius Ren, a probiotic strain with anti-tumor activity.

J Biotechnol

The Innovation Centre of Food Nutrition and Human Health (Beijing), China Agricultural University, Beijing 100083, China; Beijing Laboratory for Food Quality and Safety, China Agricultural University, Beijing 100083, China. Electronic address:

Published: September 2015

Lactobacillus salivarius Ren (LsR) (CGMCC No. 3606) is a probiotic strain that was isolated from the feces of a healthy centenarian living in Bama, Guangxi, China. Previous studies have shown that this strain decreases 4-nitroquinoline 1-oxide (4-NQO)-induced genotoxicity in vitro. It also suppresses 4-NQO-induced oral carcinogenesis and 1,2-dimethylhydrazine (DMH)-induced colorectal carcinogenesis, and therefore may be used as an adjuvant therapeutic agent for cancer. Here, we report the complete genome sequence of LsR that consists of a circular chromosome of 1751,565 bp and two plasmids (pR1, 176,951 bp; pR2, 49,848 bp).

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http://dx.doi.org/10.1016/j.jbiotec.2015.06.399DOI Listing

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