Inverse mirror plasma experimental device has been designed and fabricated for detailed experimental investigation of phase mixing and wave breaking of plasma oscillation/wave. The device produces quiescent magnetized plasma over a wide operating range using multifilamentary source with low filament spacing in cusp geometry along with a flexible transition magnetic field region between the plasma source chamber and the main chamber. Argon plasma has been produced in the device over a wide pressure range from 1.7 × 10(-5) mbar to 9 × 10(-4) mbar, achieving plasma densities in the range of ∼10(9) cm(-3)-10(12) cm(-3) and temperatures in the range of ∼1.7 eV-5 eV. To fulfill a desired prerequisite of having quiescent plasma (δn/n ≤ 1%) for realizing phase mixing of nonlinear plasma oscillation and other wave experiments, a quiescent magnetized plasma is obtained: typical quiescence, δn/n ∼ 0.5% at 10(-4) mbar and B(main) ∼ 1 kG. The potential of the multifilamentary plasma source has been experimentally explored using a flexible transition magnetic field and the usual control features of a filament discharge. Probe measurements reveal that the plasma to be axially and radially uniform, an excellent scenario for wave launching and studying its propagating and phase mixing characteristics.
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Neoplasia
December 2024
Felsenstein Medical Research Center, Beilinson Campus, Petah Tikva, Israel; Tel Aviv University, Faculty of Medicine and Health Sciences, Tel Aviv, Israel; Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel; Davidoff Cancer Center, Beilinson Campus, Petah Tikva, Israel. Electronic address:
Triple-negative breast cancer (TNBC) is an aggressive subtype that accounts for 10-15 % of breast cancer. Current treatment of high-risk early-stage TNBC includes neoadjuvant chemo-immune therapy. However, the substantial variation in immune response prompts an urgent need for new immune-targeting agents.
View Article and Find Full Text PDFAnal Chem
December 2024
Department of Chemistry and Chemical Biology, McMaster University, Hamilton, Ontario L8S 4M1, Canada.
Mass spectrometry (MS)-based metabolomics often rely on separation techniques when analyzing complex biological specimens to improve method resolution, metabolome coverage, quantitative performance, and/or unknown identification. However, low sample throughput and complicated data preprocessing procedures remain major barriers to affordable metabolomic studies that are scalable to large populations. Herein, we introduce PeakMeister as a new software tool in the R statistical environment to enable standardized processing of serum metabolomic data acquired by multisegment injection-capillary electrophoresis-mass spectrometry (MSI-CE-MS), a high-throughput separation platform (<4 min/sample) which takes advantage of a serial injection format of 13 samples within a single analytical run.
View Article and Find Full Text PDFPLoS One
December 2024
Department of Oral Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Metastasis in patients with oral squamous cell carcinoma has been associated with a poor prognosis. However, sensitive and reliable tests for monitoring their occurrence are unavailable, with the exception of PET-CT. Circulating tumor cells and cell-free DNA have emerged as promising biomarkers for determining treatment efficacy and as prognostic predictors in solid tumors such as breast cancer and colorectal cancer.
View Article and Find Full Text PDFConnect Tissue Res
December 2024
Arthroscopic Surgery Unit, Hospital Vithas Vitoria, Vitoria-Gasteiz, Spain.
Purpose: After peripheral nerve injury (PNI), prolonged denervation of the target muscle prevents adequate reinnervation even if the nerve is repaired. The aim of this work is to analyze the effect of intramuscular Platelet-Rich Plasma (PRP) in a denervated muscle due to PNI.Materials and.
View Article and Find Full Text PDFScand J Clin Lab Invest
December 2024
Department of Cardiothoracic Surgery, Anaesthesia, Perfusion, and Intensive Care, Skåne University Hospital, Lund, Sweden.
Haemolysis occurring during cardiac surgery with cardiopulmonary bypass (CPB) is assumed to be a risk factor for postoperative acute kidney injury (AKI). Plasma alpha-1 microglobulin (A1M) may have a protective role as haem scavenger. The aim of this study was to evaluate the association between AKI and the degree of haemolysis and the course of A1M concentrations during cardiac surgery, respectively.
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