Protective Effects of Dihydrocaffeic Acid, a Coffee Component Metabolite, on a Focal Cerebral Ischemia Rat Model.

Molecules

College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 130-701, Korea.

Published: June 2015

We recently reported the protective effects of chlorogenic acid (CGA) in a transient middle cerebral artery occlusion (tMCAo) rat model. The current study further investigated the protective effects of the metabolites of CGA and dihydrocaffeic acid (DHCA) was selected for further study after screening using the same tMCAo rat model. In the current study, tMCAo rats (2 h of MCAo followed by 22 h of reperfusion) were injected with various doses of DHCA at 0 and 2 h after onset of ischemia. We assessed brain damage, functional deficits, brain edema, and blood-brain barrier damage at 24 h after ischemia. For investigating the mechanism, in vitro zymography and western blotting analysis were performed to determine the expression and activation of matrix metalloproteinase (MMP)-2 and -9. DHCA (3, 10, and 30 mg/kg, i.p.) dose-dependently reduced brain infarct volume, behavioral deficits, brain water content, and Evans Blue (EB) leakage. DHCA inhibited expression and activation of MMP-2 and MMP-9. Therefore, DHCA might be one of the important metabolites of CGA and of natural products, including coffee, with protective effects on ischemia-induced neuronal damage and brain edema.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331881PMC
http://dx.doi.org/10.3390/molecules200711930DOI Listing

Publication Analysis

Top Keywords

protective effects
16
rat model
12
dihydrocaffeic acid
8
tmcao rat
8
model current
8
current study
8
metabolites cga
8
deficits brain
8
brain edema
8
expression activation
8

Similar Publications

New cinnamic acid sugar esters as potential UVB filters: Synthesis, cytotoxicity, and physicochemical properties.

Carbohydr Res

January 2025

Department of Biomolecular Sciences, University of Urbino "Carlo Bo", Campus Scientifico E. Mattei, via Ca' Le Suore 2, 61029, Urbino, PU, Italy. Electronic address:

Cinnamic Acid Sugar Ester Derivatives (CASEDs) are a class of natural compounds that exhibit several interesting biological activities. However, to date, no examples of their use in sunscreen formulations have been reported. Here, we describe the synthesis of a series of novel cinnamic acid esters of glucose (4a-g), ribose (4h) and lactose (4i) starting from the respective acetals 3.

View Article and Find Full Text PDF

Face masks are strongly believed to be the best precaution to reduce the transmission of the SARS-CoV-2 virus, which resulted in an unprecedented surge in the production and use of personal respiratory protective equipment. Unfortunately, this surge led to improper disposal of used masks. This study aimed to assess the occurrence of microplastics (MPs) in used and unused surgical and cloth masks and N95 respirators.

View Article and Find Full Text PDF

Prey depletion, interspecific competition, and the energetics of hunting in endangered African wild dogs, .

Proc Natl Acad Sci U S A

February 2025

Swansea Lab for Animal Movement, Biosciences, College of Science, Swansea University, Swansea, Wales SA2 8PP, United Kingdom.

Large herbivores are in decline in much of the world, including sub-Saharan Africa, and true apex carnivores like the lion () decline in parallel with their prey. As a consequence, competitively subordinate carnivores like the African wild dog () are simultaneously experiencing a costly reduction in resources and a beneficial reduction in dominant competitors. The net effect is not intuitively obvious, but wild dogs' density, survival, and reproduction are all low in areas that are strongly affected by prey depletion.

View Article and Find Full Text PDF

The L-type Ca channel (Ca1.2) is essential for cardiac excitation-contraction coupling. To contribute to the inward Ca flux that drives Ca-induced-Ca-release, Ca1.

View Article and Find Full Text PDF

The global dental implant market is projected to reach $9.5 billion by 2032, growing at a 6.5% compound annual growth rate due to the rising prevalence of dental diseases.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!