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Effect of type of anticoagulant, transportation time, and glucose in the culture media on neutrophil viability and function test results in dairy cattle.
PLoS One
October 2024
Faculty of Veterinary Medicine, Department of Internal Medicine, Reproduction and Population Medicine, Ghent University, Merelbeke, Ghent, Belgium.
Article Synopsis
- The study investigates how various factors affect the immune function of dairy cattle's white blood cells (PMN), especially their ability to engulf pathogens (phagocytosis) and produce reactive oxygen species (oxidative burst) using blood samples from Holstein heifers.
- Blood samples were collected in tubes with different anticoagulants (ACD vs. EDTA) and stored at a cool temperature for varying lengths of time to analyze PMN viability and functionality.
- Results showed that while PMN viability dropped significantly after 6 hours of storage for both anticoagulant types, there was no notable difference in PMN function (phagocytosis and oxidative burst) between the two anticoagulants or across the different storage times. *
Coccygeal tumours unveiled: a retrospective cohort analysis from a tertiary referral centre.
Br J Radiol
October 2024
Department of Musculoskeletal Radiology, Royal Orthopedic Hospital, Birmingham, B31 2AP, United Kingdom.
Article Synopsis
- There are not many cases of tumours on the coccyx (the tailbone), so this study looked at a lot of them to learn more.
- They found 103 cases over 15 years, mostly in older people, and most tumours were a type called chordoma.
- The study emphasizes the importance of imaging tests to help understand and treat these rare coccyx tumours better.
ISSLS PRIZE in Basic Science 2024: superiority of nucleus pulposus cell- versus mesenchymal stromal cell-derived extracellular vesicles in attenuating disc degeneration and alleviating pain.
Eur Spine J
May 2024
Department of Orthopaedic Surgery, Tokai University School of Medicine, 143 Shimokasuya, Isehara, 259-1193, Japan.
Purpose: To investigate the therapeutic potential of extracellular vesicles (EVs) derived from human nucleus pulposus cells (NPCs), with a specific emphasis on Tie2-enhanced NPCs, compared to EVs derived from human bone marrow-derived mesenchymal stromal cells (BM-MSCs) in a coccygeal intervertebral disc degeneration (IDD) rat model.
Methods: EVs were isolated from healthy human NPCs cultured under standard (NPC-EVs) and Tie2-enhancing (NPC-EVs) conditions. EVs were characterized, and their potential was assessed in vitro on degenerative NPCs in terms of cell proliferation and senescence, with or without 10 ng/mL interleukin (IL)-1β.
Background: Intervertebral disc degeneration (IDD) is a major cause of low back pain (LBP) worldwide. Sexual dimorphism, or sex-based differences, appear to exist in the severity of LBP. However, it is unknown if there are sex-based differences in the inflammatory, biomechanical, biochemical, and histological responses of intervertebral discs (IVDs).
View Article and Find Full Text PDFHuman umbilical cord-derived mesenchymal stem cells ameliorate perioperative neurocognitive disorder by inhibiting inflammatory responses and activating BDNF/TrkB/CREB signaling pathway in aged mice.
Stem Cell Res Ther
September 2023
Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, No. 1 East Jianshe Road, Zhengzhou, 450052, People's Republic of China.
Background: Perioperative neurocognitive disorder (PND) is a key complication affecting older individuals after anesthesia and surgery. Failure to translate multiple pharmacological therapies for PND from preclinical studies to clinical settings has necessitated the exploration of novel therapeutic strategies. Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) treatment has emerged as a promising therapeutic strategy for treating neurodegenerative diseases and has the potential to translate basic science into clinical practice.
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