Cirrhosis and idiopathic portal hypertension (IPH) are 2 major diseases showing portal hypertension. However, characteristics and outcomes of IPH with ascites have not yet been determined. The aim of the study was to examine the influence of ascites on the long-term clinical course of IPH.This observational study compared the long-term clinical findings including portal hemodynamics demonstrated by Doppler ultrasonography between 166 cirrhosis (87 males and 79 females; mean age ± standard deviation, 62.5 ± 11.8 years; age range, 20-89 years) and 14 IPH patients (3 males and 11 females; mean age ± standard deviation, 64.2 ± 6.6 years; age range, 51-78 years). Both groups comprised of consecutive patients from November 2007 through February 2013 and were studied retrospectively. The median observation period was 33.4 months for ascites and 34.5 months for survival.Ascites was detected in 60/166 (36.1%) and 116/166 (69.9%) cirrhosis patients and in 7/14 (50%) and 9/14 (64.3%) IPH patients, at baseline and at the end of the observation period, respectively. The cumulative incidence of ascites was 12.3% at 1 year, 35.9% at 3 years, and 59.9% at 5 years in cirrhosis, and 25% at 3 years, and 50% at 5 years in IPH (P = 0.36). Deterioration of ascites in patients showing mild ascites at baseline was found in 32.4% of cirrhosis patients and 42.9% of IPH patients (P = 0.41). Serum creatinine (mg/dl) at baseline was significantly higher in IPH patients who developed ascites (n = 2, 0.74 ± 0.14) than in those who did not (n = 5, 0.526 ± 0.06, P = 0.029). The overall survival rate appeared to favor IPH (100% at 1 year, 92.9% at 3 and 5 years; P = 0.2) more than cirrhosis (87.7% at 1 year, 75.2% at 3 years, and 63.6% at 5 years), but did not reach statistical significance. However, in patients with ascites at baseline, the survival rate was significantly better in IPH (100% at 1, 3, and 5 years, P = 0.04) than in cirrhosis (69.1% at 1 year, 43% at 3 years, 34.4% at 5 years).The presence of ascites at baseline correlated with worse survival rates in patients with cirrhosis as compared to those with IPH as the underlying etiology.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504543 | PMC |
| http://dx.doi.org/10.1097/MD.0000000000001056 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Impact of Dataset Size on 3D CNN Performance in Intracranial Hemorrhage Classification.
Diagnostics (Basel)
January 2025
Institute of Mechatronic Engineering, National Taipei University of Technology, Taipei 106, Taiwan.
This study aimed to evaluate the effect of sample size on the development of a three-dimensional convolutional neural network (3DCNN) model for predicting the binary classification of three types of intracranial hemorrhage (ICH): intraparenchymal, subarachnoid, and subdural (IPH, SAH, SDH, respectively). During the training, we compiled all images of each brain computed tomography scan into a single 3D image, which was then fed into the model to classify the presence of ICH. We divided the non-hemorrhage quantities into 20, 30, 40, 50, 100, and 150 and the ICH quantities into 20, 30, 40, and 50.
View Article and Find Full Text PDFAssessment of Attenuation in Pericarotid Fat among Patients with Carotid Plaque and Spontaneous Carotid Dissection.
AJNR Am J Neuroradiol
January 2025
Department of Radiology (R.C., R.S., L.S.), University of Cagliari, Cagliari, Italy
Background And Purpose: Changes in perivascular fat density (PFD) and its association with inflammation have been topics of interest in both atherosclerotic and nonatherosclerotic vasculopathies. The objective of this study was to assess the PFD in patients with spontaneous internal carotid artery dissection (SICAD) or carotid atherosclerotic plaque, with and without intraplaque hemorrhage (IPH).
Materials And Methods: A cross-sectional retrospective bicentric analysis of 130 patients (30 with SICAD and 100 with carotid atherosclerotic plaque) who underwent CT angiography was performed.
Non-alcoholic fatty liver disease is a strong predictor of carotid high-risk plaques as assessed by high-resolution magnetic resonance imaging.
Quant Imaging Med Surg
January 2025
Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong University, Jinan, China.
Background: Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease with a high prevalence. Recent data suggest that NAFLD may be an independent risk factor for cardiovascular disease (CVD). This study aimed to investigate the association between NAFLD and carotid high-risk plaque (HRP) as assessed by high-resolution magnetic resonance imaging (MRI), and to examine the diagnostic value of NAFLD.
View Article and Find Full Text PDFDifferentiation of Atherosclerotic Carotid Plaque Components With Dual-Energy Computed Tomography.
Invest Radiol
January 2025
From the Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, the Netherlands (M.A., J.B., T.F., A.A.P., M.E.K.); CARIM, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands (M.A., J.B., M.J.J.G., W.H.M., R.J.v.O., M.E.K.); Department of Pathology, Maastricht University Medical Center, Maastricht, the Netherlands (M.J.J.G.); Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences: Atherosclerosis & Ischemic Syndrome; Amsterdam Infection and Immunity: Inflammatory Diseases; Amsterdam UMC Location University of Amsterdam, Amsterdam, the Netherlands (M.J.J.G.); Department of Neurology, Zuyderland Medical Center, Heerlen, the Netherlands (T.H.C.M.L.S.); Department of Neurology, Zuyderland Medical Center, Sittard, the Netherlands (N.P.v.O.); Department of Vascular Surgery, Maastricht University Medical Center, Maastricht, the Netherlands (J.-W.H.C.D.); Department of Clinical Neurophysiology, Maastricht University Medical Center, Maastricht, the Netherlands (W.H.M.); Department of Neurology, Maastricht University Medical Center, Maastricht, the Netherlands (R.J.v.O.); and School for Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, the Netherlands (A.A.P.).
Objectives: Carotid plaque vulnerability is a strong predictor of recurrent ipsilateral stroke, but differentiation of plaque components using conventional computed tomography (CT) is suboptimal. The aim of our study was to evaluate the ability of dual-energy CT (DECT) to characterize atherosclerotic carotid plaque components based on the effective atomic number and effective electron density using magnetic resonance imaging (MRI) and, where possible, histology as the reference standard.
Materials And Methods: Patients with recent cerebral ischemia and a ≥2-mm carotid plaque underwent computed tomography angiography and MRI.
Monocyte count as an independent predictor of high thrombus burden in ST-elevation myocardial infarction patients undergoing percutaneous coronary intervention: A systematic review and meta-analysis.
Medicine (Baltimore)
January 2025
Kabir Medical College, Gandhara University, Peshawar, Pakistan.
Background: Due to the lack of a prior comprehensive review and meta-analysis, the relationship between monocyte count and thrombus load in ST-elevation myocardial infarction (STEMI) patients undergoing percutaneous coronary intervention (PCI) has not been adequately established.
Methods: This was a systematic review and meta-analysis of multiple cohorts (retrospective and prospective) and cross-sectional studies.We queried electronic databases (PubMed, Google Scholar, and Cochrane Central) from their inception to April 2022.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!