AI Article Synopsis
- - Ischemia/reperfusion injury occurs after kidney transplantation and significantly affects both short-term and long-term outcomes for the graft, leading to problems like delayed graft function and chronic dysfunction.
- - This injury triggers an inflammatory response influenced by cellular changes, energy metabolism issues, and various forms of cell death, including apoptosis, necrosis, and a newer form called necroptosis.
- - Understanding the mechanisms behind ischemia/reperfusion injury is crucial for developing strategies to prevent or treat it, ultimately improving kidney transplant success rates.
Article Abstract
Ischemia/reperfusion injury is an unavoidable relevant consequence after kidney transplantation and influences short term as well as long-term graft outcome. Clinically ischemia/reperfusion injury is associated with delayed graft function, graft rejection, chronic rejection and chronic graft dysfunction. Ischemia/reperfusion affects many regulatory systems at the cellular level as well as in the renal tissue that result in a distinct inflammatory reaction of the kidney graft. Underlying factors of ischemia reperfusion include energy metabolism, cellular changes of the mitochondria and cellular membranes, initiation of different forms of cell death-like apoptosis and necrosis together with a recently discovered mixed form termed necroptosis. Chemokines and cytokines together with other factors promote the inflammatory response leading to activation of the innate immune system as well as the adaptive immune system. If the inflammatory reaction continues within the graft tissue, a progressive interstitial fibrosis develops that impacts long-term graft outcome. It is of particular importance in kidney transplantation to understand the underlying mechanisms and effects of ischemia/reperfusion on the graft as this knowledge also opens strategies to prevent or treat ischemia/reperfusion injury after transplantation in order to improve graft outcome.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4478600 | PMC |
| http://dx.doi.org/10.5500/wjt.v5.i2.52 | DOI Listing |
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